Next Article in Journal
The Anti-Cancer Effects of Frondoside A
Next Article in Special Issue
Effects of the Combination of Gliotoxin and Adriamycin on the Adriamycin-Resistant Non-Small-Cell Lung Cancer A549 Cell Line
Previous Article in Journal
A Comparative Study on Asymmetric Reduction of Ketones Using the Growing and Resting Cells of Marine-Derived Fungi
Previous Article in Special Issue
A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway
Open AccessArticle

Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs

School of Environment and Life Sciences, Cockcroft Building, University of Salford, Manchester M5 4WT, UK
*
Author to whom correspondence should be addressed.
Mar. Drugs 2018, 16(2), 63; https://doi.org/10.3390/md16020063
Received: 10 January 2018 / Revised: 8 February 2018 / Accepted: 12 February 2018 / Published: 15 February 2018
(This article belongs to the Collection Marine Compounds and Cancer)
Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identified, and characterised, a novel marine polysaccharide with the potential to be developed as an anticancer agent. Sulphated polysaccharides isolated from the common cockle (Cerastoderma edule) were shown to have antiproliferative activity on chronic myelogenous leukaemia and relapsed acute lymphoblastic leukaemia cell lines. Disaccharide and monosaccharide analysis of these marine polysaccharides confirmed the presence of glycosaminoglycan-like structures that were enriched in ion-exchange purified fractions containing antiproliferative activity. The antiproliferative activity of these glycosaminoglycan-like marine polysaccharides was shown to be susceptible to heparinase but not chondrotinase ABC digestion. This pattern of enzymatic and antiproliferative activity has not previously been seen, with either marine or mammalian glycosaminoglycans. As such, our findings suggest we have identified a new type of marine derived heparan sulphate/heparin-like polysaccharide with potent anticancer properties. View Full-Text
Keywords: marine mollusc; glycosaminoglycans; antiproliferative; anticancer; heparan sulphate marine mollusc; glycosaminoglycans; antiproliferative; anticancer; heparan sulphate
Show Figures

Figure 1

MDPI and ACS Style

Aldairi, A.F.; Ogundipe, O.D.; Pye, D.A. Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs. Mar. Drugs 2018, 16, 63.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop