Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs
School of Environment and Life Sciences, Cockcroft Building, University of Salford, Manchester M5 4WT, UK
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Mar. Drugs 2018, 16(2), 63; https://doi.org/10.3390/md16020063
Received: 10 January 2018
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Revised: 8 February 2018
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Accepted: 12 February 2018
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Published: 15 February 2018
(This article belongs to the Collection Marine Compounds and Cancer)
Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identified, and characterised, a novel marine polysaccharide with the potential to be developed as an anticancer agent. Sulphated polysaccharides isolated from the common cockle (Cerastoderma edule) were shown to have antiproliferative activity on chronic myelogenous leukaemia and relapsed acute lymphoblastic leukaemia cell lines. Disaccharide and monosaccharide analysis of these marine polysaccharides confirmed the presence of glycosaminoglycan-like structures that were enriched in ion-exchange purified fractions containing antiproliferative activity. The antiproliferative activity of these glycosaminoglycan-like marine polysaccharides was shown to be susceptible to heparinase but not chondrotinase ABC digestion. This pattern of enzymatic and antiproliferative activity has not previously been seen, with either marine or mammalian glycosaminoglycans. As such, our findings suggest we have identified a new type of marine derived heparan sulphate/heparin-like polysaccharide with potent anticancer properties.
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MDPI and ACS Style
Aldairi, A.F.; Ogundipe, O.D.; Pye, D.A. Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs. Mar. Drugs 2018, 16, 63. https://doi.org/10.3390/md16020063
AMA Style
Aldairi AF, Ogundipe OD, Pye DA. Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs. Marine Drugs. 2018; 16(2):63. https://doi.org/10.3390/md16020063
Chicago/Turabian StyleAldairi, Abdullah Faisal, Olanrewaju Dorcas Ogundipe, and David Alexander Pye. 2018. "Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs" Marine Drugs 16, no. 2: 63. https://doi.org/10.3390/md16020063
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