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Open AccessReview

Marine Compound Xyloketal B as a Potential Drug Development Target for Neuroprotection

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Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
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Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
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Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China
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Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-Sen University), Department of Education of Guangdong Province, Guangzhou 510080, China
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Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
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Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
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Authors to whom correspondence should be addressed.
Mar. Drugs 2018, 16(12), 516; https://doi.org/10.3390/md16120516
Received: 27 November 2018 / Revised: 14 December 2018 / Accepted: 14 December 2018 / Published: 19 December 2018
Xyloketal B is a natural compound isolated from the mangrove fungus, Xylaria sp. in the South China Sea. In the past decade, studies have shown that xyloketal B exhibits anti-oxidative, anti-inflammatory, and anti-apoptotic abilities and may serve as a treatment for ischemic stroke. Xyloketal B has been shown to interact with both neurons and residential microglial cells and regulate a number of proteins involved in the apoptotic events during ischemia. Such mechanisms include inhibition of specific NADPH oxidase subunits, upregulation of HO-1, increase of Bcl-1/Bax ratio, and downregulation of TLR4 receptor. Both in vitro and in vivo stroke models have validated its potential in preventing ischemia-induced neuronal cell death. This review summarizes our current understanding of the effects of xyloketal B in ischemic conditions. As stroke ranks second in the causes of mortality worldwide and still lacks effective treatment, it is necessary to seek novel therapeutic options. Understanding the role of xyloketal B in ischemic stroke could reveal a new aspect of stroke treatment. View Full-Text
Keywords: marine compound; xyloketal B; neuroprotection; antioxidative; drug development marine compound; xyloketal B; neuroprotection; antioxidative; drug development
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MDPI and ACS Style

Gong, H.; Luo, Z.; Chen, W.; Feng, Z.-P.; Wang, G.-L.; Sun, H.-S. Marine Compound Xyloketal B as a Potential Drug Development Target for Neuroprotection. Mar. Drugs 2018, 16, 516.

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