Bromopyrrole Alkaloids from the Sponge Agelas kosrae
AbstractTwo new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively. View Full-Text
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Kwon, O.-S.; Kim, D.; Kim, H.; Lee, Y.-J.; Lee, H.-S.; Sim, C.J.; Oh, D.-C.; Lee, S.K.; Oh, K.-B.; Shin, J. Bromopyrrole Alkaloids from the Sponge Agelas kosrae. Mar. Drugs 2018, 16, 513.
Kwon O-S, Kim D, Kim H, Lee Y-J, Lee H-S, Sim CJ, Oh D-C, Lee SK, Oh K-B, Shin J. Bromopyrrole Alkaloids from the Sponge Agelas kosrae. Marine Drugs. 2018; 16(12):513.Chicago/Turabian Style
Kwon, Oh-Seok; Kim, Donghwa; Kim, Heegyu; Lee, Yeon-Ju; Lee, Hyi-Seung; Sim, Chung J.; Oh, Dong-Chan; Lee, Sang K.; Oh, Ki-Bong; Shin, Jongheon. 2018. "Bromopyrrole Alkaloids from the Sponge Agelas kosrae." Mar. Drugs 16, no. 12: 513.
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