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Bromopyrrole Alkaloids from the Sponge Agelas kosrae

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
3
Marine Natural Products Laboratory, Korea Institute of Ocean Science and Technology, P.O. Box 29, Seoul 425-600, Korea
4
Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2018, 16(12), 513; https://doi.org/10.3390/md16120513
Received: 28 November 2018 / Revised: 12 December 2018 / Accepted: 13 December 2018 / Published: 17 December 2018
(This article belongs to the Special Issue Bioactive Compounds from Marine Sponges)
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Abstract

Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively. View Full-Text
Keywords: sceptrin; pyrrole-imidazole alkaloids; marine sponge; anti-angiogenesis; isocitrate lyase; bioactive marine natural products sceptrin; pyrrole-imidazole alkaloids; marine sponge; anti-angiogenesis; isocitrate lyase; bioactive marine natural products
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Kwon, O.-S.; Kim, D.; Kim, H.; Lee, Y.-J.; Lee, H.-S.; Sim, C.J.; Oh, D.-C.; Lee, S.K.; Oh, K.-B.; Shin, J. Bromopyrrole Alkaloids from the Sponge Agelas kosrae. Mar. Drugs 2018, 16, 513.

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