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Mar. Drugs 2018, 16(11), 441; https://doi.org/10.3390/md16110441

Protective Effect of Pyrogallol-Phloroglucinol-6,6-Bieckol from Ecklonia cava on Monocyte-Associated Vascular Dysfunction

1
Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea
2
Department of Anatomy & Cell Biology, Graduate School of Medicine, Gachon University, Incheon 21936, Korea
3
Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Korea
4
Department of Marine Life Science, Jeju National University, Jeju 63243, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 23 October 2018 / Revised: 27 October 2018 / Accepted: 6 November 2018 / Published: 9 November 2018
(This article belongs to the Special Issue Marine Anti-inflammatory Agents)
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Abstract

Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract of E. cava. These four major compounds were isolated and their effects were examined on monocyte-associated vascular inflammation and dysfunctions. Pyrogallol-phloroglucinol-6,6-bieckol (PPB) significantly inhibited monocyte migration in vitro by reducing levels of inflammatory macrophage differentiation and of its related molecular factors. In addition, PPB protected against monocyte-associated endothelial cell death by increasing the phosphorylations of PI3K-AKT and AMPK, decreasing caspase levels, and reducing monocyte-associated vascular smooth muscle cell proliferation and migration by decreasing the phosphorylations of ERK and AKT. The results of this study show that four compounds were effective for reduction of monocyte-associated vascular inflammation and dysfunctions, but PPB might be more useful for the treatment of vascular dysfunction in diseases associated with poor circulation. View Full-Text
Keywords: poor blood circulation; Ecklonia cava; phlorotannins; pyrogallol-phloroglucinol-6,6-bieckol; functional ingredients; endothelial cell death; vascular smooth muscle cell proliferation and migration; inflammation poor blood circulation; Ecklonia cava; phlorotannins; pyrogallol-phloroglucinol-6,6-bieckol; functional ingredients; endothelial cell death; vascular smooth muscle cell proliferation and migration; inflammation
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Oh, S.; Son, M.; Lee, H.S.; Kim, H.-S.; Jeon, Y.-J.; Byun, K. Protective Effect of Pyrogallol-Phloroglucinol-6,6-Bieckol from Ecklonia cava on Monocyte-Associated Vascular Dysfunction. Mar. Drugs 2018, 16, 441.

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