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Mar. Drugs 2018, 16(11), 405; https://doi.org/10.3390/md16110405

Excavatolide-B Enhances Contextual Memory Retrieval via Repressing the Delayed Rectifier Potassium Current in the Hippocampus

1
Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan
2
Institute of Biomedical Sciences, Academia Sinica, 128, Academia road, Section 2, Nangang, Taipei 115, Taiwan
3
Cardiovascular and Metabolomics Research Center, Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan
4
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
5
Institute of Medical Sciences, Tzu Chi University, Hualien 970, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 September 2018 / Revised: 21 October 2018 / Accepted: 22 October 2018 / Published: 25 October 2018
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Abstract

Memory retrieval dysfunction is a symptom of schizophrenia, autism spectrum disorder (ASD), and absence epilepsy (AE), as well as an early sign of Alzheimer’s disease. To date, few drugs have been reported to enhance memory retrieval. Here, we found that a coral-derived natural product, excavatolide-B (Exc-B), enhances contextual memory retrieval in both wild-type and Cav3.2−/− mice via repressing the delayed rectifier potassium current, thus lowering the threshold for action potential initiation and enhancing induction of long-term potentiation (LTP). The human CACNA1H gene encodes a T-type calcium channel (Cav3.2), and its mutation is associated with schizophrenia, ASD, and AE, which are all characterized by abnormal memory function. Our previous publication demonstrated that Cav3.2−/− mice exhibit impaired contextual-associated memory retrieval, whilst their retrieval of spatial memory and auditory cued memory remain intact. The effect of Exc-B on enhancing the retrieval of context-associated memory provides a hope for novel drug development. View Full-Text
Keywords: coral; excavatolide-B; Cav3.2−/− mice; T-type calcium channel; potassium current; long-term potentiation; autism spectrum disorder; absence epilepsy; memory coral; excavatolide-B; Cav3.2−/− mice; T-type calcium channel; potassium current; long-term potentiation; autism spectrum disorder; absence epilepsy; memory
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Huang, I.Y.; Hsu, Y.-L.; Chen, C.-C.; Chen, M.-F.; Wen, Z.-H.; Huang, H.-T.; Liu, I.Y. Excavatolide-B Enhances Contextual Memory Retrieval via Repressing the Delayed Rectifier Potassium Current in the Hippocampus. Mar. Drugs 2018, 16, 405.

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