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Mar. Drugs 2018, 16(10), 365;

High Throughput Identification of Antihypertensive Peptides from Fish Proteome Datasets

1,* and 2,3,*
School of Applied Chemistry and Biotechnology, Shenzhen Polytechnic, Shenzhen 518055, China
BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI Academy of Marine Sciences, BGI Marine, BGI, Shenzhen 518083, China
Authors to whom correspondence should be addressed.
Received: 30 August 2018 / Revised: 21 September 2018 / Accepted: 24 September 2018 / Published: 2 October 2018
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Antihypertensive peptides (AHTPs) are a group of small peptides with the main role to block key enzymes or receptors in the angiotensin genesis pathway. A great number of AHTPs have been isolated or digested from natural food resources; however, comprehensive studies on comparisons of AHTPs in various species from the perspective of big data are rare. Here, we established a simplified local AHTP database, and performed in situ mapping for high throughput identification of AHTPs with high antihypertensive activity from high-quality whole proteome datasets of 18 fish species. In the 35 identified AHTPs with reported high activity, we observed that Gly-Leu-Pro, Leu-Pro-Gly, and Val-Ser-Val are the major components of fish proteins, and AHTP hit numbers in various species demonstrated a similar distributing pattern. Interestingly, Atlantic salmon (Salmo salar) is in possession of far more abundant AHTPs compared with other fish species. In addition, collagen subunit protein is the largest group with more matching AHTPs. Further exploration of two collagen subunits (col4a5 and col8a1) in more fish species suggested that the hit pattern of these conserved proteins among teleost is almost the same, and their phylogeny is consistent with the evolution of these fish species. In summary, our present study provides basic information for the relationship of AHTPs with fish proteins, which sheds light on rapid discovery of marine drugs or food additives from fish protein hydrolysates to alleviate hypertension. View Full-Text
Keywords: antihypertensive peptide; fish protein hydrolysate; high throughput identification; hypertension; collagen antihypertensive peptide; fish protein hydrolysate; high throughput identification; hypertension; collagen

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Yi, Y.; Lv, Y.; Zhang, L.; Yang, J.; Shi, Q. High Throughput Identification of Antihypertensive Peptides from Fish Proteome Datasets. Mar. Drugs 2018, 16, 365.

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