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Mar. Drugs 2018, 16(10), 358; https://doi.org/10.3390/md16100358

Peniginsengins B–E, New Farnesylcyclohexenones from the Deep Sea-Derived Fungus Penicillium sp. YPGA11

1
College of Pharmacy, Henan University, Kaifeng 475004, China
2
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China
3
Eucommia Ulmoides Cultivation and Utilization of Henan Engineering Laboratory, Kaifeng 475004, China
4
College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 6 September 2018 / Revised: 21 September 2018 / Accepted: 27 September 2018 / Published: 1 October 2018
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Abstract

Chemical examination of the EtOAc extract of the deep sea-derived fungus Penicillium sp. YPGA11 resulted in the isolation of four new farnesylcyclohexenones, peniginsengins B–E (14), and a known analog peniginsengin A (5). The structures of compounds 14 were determined on the basis of comprehensive analyses of the nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data, and the absolute configurations of 1, 2, and 4 were determined by comparisons of experimental electronic circular dichroism (ECD) with calculated ECD spectra. Compounds 15, characterized by a highly oxygenated 1-methylcyclohexene unit and a (4E,8E)-4,8-dimethyldeca-4,8-dienoic acid side chain, are rarely found in nature. Compounds 24 exhibited antibacterial activity against Staphylococcus aureus. View Full-Text
Keywords: Penicillium sp.; deep sea-derived fungus; farnesylcyclohexenones; antibacterial Penicillium sp.; deep sea-derived fungus; farnesylcyclohexenones; antibacterial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Cheng, Z.; Xu, W.; Liu, L.; Li, S.; Yuan, W.; Luo, Z.; Zhang, J.; Cheng, Y.; Li, Q. Peniginsengins B–E, New Farnesylcyclohexenones from the Deep Sea-Derived Fungus Penicillium sp. YPGA11. Mar. Drugs 2018, 16, 358.

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