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Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives

Institute of Protein Biochemistry, National Research Council, I-80131 Naples, Italy
Laboratoire d’Ingénierie des Systèmes Biologiques et des Procédés, INSA, 31400 Toulouse, France
Stazione Zoologica “Anthon Dorn”, Villa Comunale, I-80121 Naples, Italy
Department of Biology, University of Florence, Sesto Fiorentino, I-50019 Florence, Italy
Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen, Scotland AB24 3UE, UK
Author to whom correspondence should be addressed.
These authors equally contributed to the work.
Mar. Drugs 2018, 16(10), 355;
Received: 23 July 2018 / Revised: 25 September 2018 / Accepted: 27 September 2018 / Published: 29 September 2018
(This article belongs to the Special Issue Marine Bacteria as Sources of Bioactive Compounds)
The increasing emergence of new forms of multidrug resistance among human pathogenic bacteria, coupled with the consequent increase of infectious diseases, urgently requires the discovery and development of novel antimicrobial drugs with new modes of action. Most of the antibiotics currently available on the market were obtained from terrestrial organisms or derived semisynthetically from fermentation products. The isolation of microorganisms from previously unexplored habitats may lead to the discovery of lead structures with antibiotic activity. The deep-sea environment is a unique habitat, and deep-sea microorganisms, because of their adaptation to this extreme environment, have the potential to produce novel secondary metabolites with potent biological activities. This review covers novel antibiotics isolated from deep-sea microorganisms. The chemical classes of the compounds, their bioactivities, and the sources of organisms are outlined. Furthermore, the authors report recent advances in techniques and strategies for the exploitation of deep-sea microorganisms. View Full-Text
Keywords: antibiotics; deep-sea; marine microorganisms; extreme habitat; marine sediments antibiotics; deep-sea; marine microorganisms; extreme habitat; marine sediments
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MDPI and ACS Style

Tortorella, E.; Tedesco, P.; Palma Esposito, F.; January, G.G.; Fani, R.; Jaspars, M.; De Pascale, D. Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives. Mar. Drugs 2018, 16, 355.

AMA Style

Tortorella E, Tedesco P, Palma Esposito F, January GG, Fani R, Jaspars M, De Pascale D. Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives. Marine Drugs. 2018; 16(10):355.

Chicago/Turabian Style

Tortorella, Emiliana, Pietro Tedesco, Fortunato Palma Esposito, Grant Garren January, Renato Fani, Marcel Jaspars, and Donatella De Pascale. 2018. "Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives" Marine Drugs 16, no. 10: 355.

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