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Marine Alkylpurines: A Promising Group of Bioactive Marine Natural Products

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Department of Pharmaceutical Sciences, Medicinal Chemistry Section, Pharmacy Faculty, CIETUS, IBSAL, University of Salamanca, E-37007 Salamanca, Spain
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Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, E-37008 Salamanca, Spain
*
Author to whom correspondence should be addressed.
Dedicated to Arturo San Feliciano on the occasion of his 70th birthday for his contribution to Natural Product Chemistry.
Mar. Drugs 2018, 16(1), 6; https://doi.org/10.3390/md16010006
Received: 30 November 2017 / Revised: 16 December 2017 / Accepted: 19 December 2017 / Published: 1 January 2018
Marine secondary metabolites with a purine motif in their structure are presented in this review. The alkylpurines are grouped according to the size of the alkyl substituents and their location on the purine ring. Aspects related to the marine source, chemical structure and biological properties are considered together with synthetic approaches towards the natural products and bioactive analogues. This review contributes to studies of structure–activity relationships for these metabolites and highlights the potential of the sea as a source of new lead compounds in diverse therapeutic fields. View Full-Text
Keywords: marine natural products; purines; methylpurines; alkylpurines; terpenylpurines; cytotoxicity; antimicrobial activity marine natural products; purines; methylpurines; alkylpurines; terpenylpurines; cytotoxicity; antimicrobial activity
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García, P.A.; Valles, E.; Díez, D.; Castro, M.-Á. Marine Alkylpurines: A Promising Group of Bioactive Marine Natural Products. Mar. Drugs 2018, 16, 6.

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