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Keywords = terpenylpurines

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32 pages, 7672 KiB  
Review
Marine Alkylpurines: A Promising Group of Bioactive Marine Natural Products
by Pablo A. García, Elena Valles, David Díez and María-Ángeles Castro
Mar. Drugs 2018, 16(1), 6; https://doi.org/10.3390/md16010006 - 1 Jan 2018
Cited by 16 | Viewed by 7510
Abstract
Marine secondary metabolites with a purine motif in their structure are presented in this review. The alkylpurines are grouped according to the size of the alkyl substituents and their location on the purine ring. Aspects related to the marine source, chemical structure and [...] Read more.
Marine secondary metabolites with a purine motif in their structure are presented in this review. The alkylpurines are grouped according to the size of the alkyl substituents and their location on the purine ring. Aspects related to the marine source, chemical structure and biological properties are considered together with synthetic approaches towards the natural products and bioactive analogues. This review contributes to studies of structure–activity relationships for these metabolites and highlights the potential of the sea as a source of new lead compounds in diverse therapeutic fields. Full article
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17 pages, 175 KiB  
Review
Terpenyl-Purines from the Sea
by Marina Gordaliza
Mar. Drugs 2009, 7(4), 833-849; https://doi.org/10.3390/md7040833 - 23 Dec 2009
Cited by 41 | Viewed by 15685
Abstract
Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity [...] Read more.
Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis, and also an important cytotoxic activity against several cancer cell lines, including multidrug-resistant ones. Of particular interest in this context are the asmarines (tetrahydro[1,4]diazepino[1,2,3-g,h]purines), which have shown potent antiproliferative activity against several types of human cancer cell lines. This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives. Full article
(This article belongs to the Special Issue Alkaloid Analogs)
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