Next Article in Journal
Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action
Next Article in Special Issue
Biogenetic Relationships of Bioactive Sponge Merotriterpenoids
Previous Article in Journal
New Marine Antifouling Compounds from the Red Alga Laurencia sp.
Previous Article in Special Issue
Producing Novel Fibrinolytic Isoindolinone Derivatives in Marine Fungus Stachybotrys longispora FG216 by the Rational Supply of Amino Compounds According to Its Biosynthesis Pathway
Open AccessReview

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

Department of Food Biosciences, Teagasc Food Research Centre Ashtown, Dublin D15 KN3K, Ireland
School of Microbiology, University College Cork, Western Road, Cork City T12 YN60, Ireland
Department of Immunology, Microbiology and Parasitology, Faculty of Science, University of the Basque Country, (UPV/EHU), 48940 Leioa, Spain
Author to whom correspondence should be addressed.
Mar. Drugs 2017, 15(9), 272;
Received: 20 July 2017 / Revised: 12 August 2017 / Accepted: 23 August 2017 / Published: 28 August 2017
(This article belongs to the Special Issue Genome Mining and Marine Microbial Natural Products)
The marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds. View Full-Text
Keywords: antimicrobial; marine natural products (MNPs); secondary metabolites; antibacterial; antifungal; genome mining antimicrobial; marine natural products (MNPs); secondary metabolites; antibacterial; antifungal; genome mining
Show Figures

Graphical abstract

MDPI and ACS Style

Choudhary, A.; Naughton, L.M.; Montánchez, I.; Dobson, A.D.W.; Rai, D.K. Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials. Mar. Drugs 2017, 15, 272.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop