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New Marine Antifouling Compounds from the Red Alga Laurencia sp.

Graduate School of Environmental Science, Hokkaido University, Sapporo 060-0810, Japan
Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, Sabah 88400, Malaysia
National Institute of Technology, Asahikawa College, Asahikawa 071-8142, Japan
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
Faculty of Agriculture, University of the Ryukyus, Senbaru 1, Nishihara, Okinawa 903-0213, Japan
Coastal Branch of Natural History Museum and Institute, Chiba, 123 Yoshio, Katsuura, Chiba 299-5242, Japan
CERES, Inc., 1-4-5 Midori, Abiko, Chiba 270-1153, Japan
Environmental Science Research Laboratory, Central Research Institute of Electric Power Industry, 1646 Abiko, Abiko, Chiba 270-1194, Japan
Faculty of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan
Author to whom correspondence should be addressed.
Mar. Drugs 2017, 15(9), 267;
Received: 31 July 2017 / Revised: 20 August 2017 / Accepted: 23 August 2017 / Published: 28 August 2017
(This article belongs to the Special Issue Antifouling Marine Natural Products)
PDF [650 KB, uploaded 28 August 2017]


Six new compounds, omaezol, intricatriol, hachijojimallenes A and B, debromoaplysinal, and 11,12-dihydro-3-hydroxyretinol have been isolated from four collections of Laurencia sp. These structures were determined by MS and NMR analyses. Their antifouling activities were evaluated together with eight previously known compounds isolated from the same samples. In particular, omaezol and hachijojimallene A showed potent activities (EC50 = 0.15–0.23 µg/mL) against larvae of the barnacle Amphibalanus amphitrite. View Full-Text
Keywords: antifouling; biofouling; barnacle; terpenoid; acetogenin; Laurencia; Rhodophyta antifouling; biofouling; barnacle; terpenoid; acetogenin; Laurencia; Rhodophyta

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Oguri, Y.; Watanabe, M.; Ishikawa, T.; Kamada, T.; Vairappan, C.S.; Matsuura, H.; Kaneko, K.; Ishii, T.; Suzuki, M.; Yoshimura, E.; Nogata, Y.; Okino, T. New Marine Antifouling Compounds from the Red Alga Laurencia sp.. Mar. Drugs 2017, 15, 267.

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