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Establishing the Secondary Metabolite Profile of the Marine Fungus: Tolypocladium geodes sp. MF458 and Subsequent Optimisation of Bioactive Secondary Metabolite Production
Open AccessArticle

Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129

Université de Brest, EA 3882, Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, IBSAM, 6 Rue de l’université, 29000 Quimper, France
COrInt, UMR CNRS 6226 & Université de Rennes, 35043 Rennes, France
Kinase Inhibitor Specialized Screening facility (KISSf), Station Biologique de Roscoff, Centre National de la Recherche Scientifique (CNRS) USR 3151 (Protein Phosphorylation and Human Diseases), CS 90074, Roscoff CEDEX 29688, France
Author to whom correspondence should be addressed.
Present address: Université de Brest, EA 3884, Laboratoire de Biotechnologie et Chimie Marines, IUEM, 6 Rue de l’université, 29000 Quimper, France.
Academic Editor: Peer B. Jacobson
Mar. Drugs 2017, 15(4), 111;
Received: 14 December 2016 / Revised: 24 March 2017 / Accepted: 28 March 2017 / Published: 7 April 2017
(This article belongs to the Special Issue Marine Fungal Natural Products)
Four bioactive compounds have been isolated from the fungus Oidiodendron griseum UBOCC-A-114129 cultivated from deep subsurface sediment. They were structurally characterized using a combination of LC–MS/MS and NMR analyses as fuscin and its derivatives (dihydrofuscin, dihydrosecofuscin, and secofuscin) and identified as polyketides. Albeit those compounds were already obtained from terrestrial fungi, this is the first report of their production by an Oidiodendron species and by the deepest subseafloor isolate ever studied for biological activities. We report a weak antibacterial activity of dihydrosecofuscin and secofuscin mainly directed against Gram-positive bacteria (Minimum Inhibitory Concentration (MIC) equal to Minimum Bactericidal Concentration (MBC), in the range of 100 μg/mL). The activity on various protein kinases was also analyzed and revealed a significant inhibition of CDC2-like kinase-1 (CLK1) by dihysecofuscin. View Full-Text
Keywords: deep subseafloor fungi; bioactivities; antibacterial; anti-kinase deep subseafloor fungi; bioactivities; antibacterial; anti-kinase
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MDPI and ACS Style

Navarri, M.; Jégou, C.; Bondon, A.; Pottier, S.; Bach, S.; Baratte, B.; Ruchaud, S.; Barbier, G.; Burgaud, G.; Fleury, Y. Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129. Mar. Drugs 2017, 15, 111.

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