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Mar. Drugs 2017, 15(12), 374; https://doi.org/10.3390/md15120374

Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula

1
School of Ocean Sciences, China University of Geosciences, Beijing 100083, China
2
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
3
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
4
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
*
Authors to whom correspondence should be addressed.
Received: 3 November 2017 / Revised: 23 November 2017 / Accepted: 23 November 2017 / Published: 1 December 2017
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Abstract

This study describes an investigation into secondary metabolites that are produced by a marine red alga, Symphyocladia latiuscula, which was collected from coastal waters off Qingdao, China. A combination of normal, reversed phase, and gel chromatography was used to isolate six citric acid derived natural products, aconitates A–F (16), together with two known and ten new polybrominated phenols, symphyocladins C/D (7a/b), and symphyocladins H–Q (8a/b, 9a/b and 1015), respectively. Structure elucidation was achieved by detailed spectroscopic (including X-ray crystallographic) analysis. We propose a plausible and convergent biosynthetic pathway involving a key quinone methide intermediate, linking aconitates and symphyocladins. View Full-Text
Keywords: marine red alga; Symphyocladia latiuscula; bromophenols; symphyocladins; aconitates marine red alga; Symphyocladia latiuscula; bromophenols; symphyocladins; aconitates
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Xu, X.; Yang, H.; Khalil, Z.G.; Yin, L.; Xiao, X.; Neupane, P.; Bernhardt, P.V.; Salim, A.A.; Song, F.; Capon, R.J. Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula. Mar. Drugs 2017, 15, 374.

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