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Keywords = symphyocladins

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Article
Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula
by Xiuli Xu, Haijin Yang, Zeinab G. Khalil, Liyuan Yin, Xue Xiao, Pratik Neupane, Paul V. Bernhardt, Angela A. Salim, Fuhang Song and Robert J. Capon
Mar. Drugs 2017, 15(12), 374; https://doi.org/10.3390/md15120374 - 1 Dec 2017
Cited by 13 | Viewed by 4818
Abstract
This study describes an investigation into secondary metabolites that are produced by a marine red alga, Symphyocladia latiuscula, which was collected from coastal waters off Qingdao, China. A combination of normal, reversed phase, and gel chromatography was used to isolate six citric [...] Read more.
This study describes an investigation into secondary metabolites that are produced by a marine red alga, Symphyocladia latiuscula, which was collected from coastal waters off Qingdao, China. A combination of normal, reversed phase, and gel chromatography was used to isolate six citric acid derived natural products, aconitates A–F (16), together with two known and ten new polybrominated phenols, symphyocladins C/D (7a/b), and symphyocladins H–Q (8a/b, 9a/b and 1015), respectively. Structure elucidation was achieved by detailed spectroscopic (including X-ray crystallographic) analysis. We propose a plausible and convergent biosynthetic pathway involving a key quinone methide intermediate, linking aconitates and symphyocladins. Full article
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