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Mar. Drugs 2017, 15(11), 354; https://doi.org/10.3390/md15110354

Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review

1
Ocean College, Zhejiang University, Hangzhou 310058, China
2
Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310012, China
3
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
This review is dedicated to the memory of the late Professor Ernesto Fattorusso on the occasion of what would have been his 80th birthday.
These two authors contributed equally to this article.
*
Authors to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 1 November 2017 / Accepted: 3 November 2017 / Published: 10 November 2017
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Abstract

Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increase in the number of deaths caused by cancer due to chemotherapy resistance as well. Accordingly, marine cyanobacteria, being the oldest prokaryotic microorganisms belonging to a monophyletic group, have proven themselves as being able to generate pharmaceutically important natural products. They have long been known to produce distinct and structurally complex secondary metabolites including peptides, polyketides, alkaloids, lipids, and terpenes with potent biological properties and applications. As such, this review will focus on recently published novel compounds isolated from marine cyanobacteria along with their potential bioactivities such as antibacterial, antifungal, anticancer, anti-tuberculosis, immunosuppressive and anti-inflammatory capacities. Moreover, various structural classes, as well as their technological uses will also be discussed. View Full-Text
Keywords: cyanobacteria; secondary metabolites; biological properties and applications cyanobacteria; secondary metabolites; biological properties and applications
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Shah, S.A.A.; Akhter, N.; Auckloo, B.N.; Khan, I.; Lu, Y.; Wang, K.; Wu, B.; Guo, Y.-W. Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review. Mar. Drugs 2017, 15, 354.

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