Next Article in Journal
5-Alkylresorcinol Derivatives from the Bryozoan Schizomavella mamillata: Isolation, Synthesis, and Antioxidant Activity
Next Article in Special Issue
Structural Diversity, Biological Properties and Applications of Natural Products from Cyanobacteria. A Review
Previous Article in Journal
Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation
Previous Article in Special Issue
Recent Advances in the Isolation, Synthesis and Biological Activity of Marine Guanidine Alkaloids
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Mar. Drugs 2017, 15(11), 335;

Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones

The NeaNat Group, Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy
Italian Malaria Network—Centro Interuniversitario di Ricerche Sulla Malaria (CIRM), Dipartimento di Medicina Sperimentale e Scienze Biochimiche, via Del Giochetto, 06122 Perugia, Italy
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, Fisciano, 84084 Salerno, Italy
Departament de Química Analítica, Facultat de Química, Universitat de València, Dr. Moliner 50, Burjassot, 46100 Valencia, Spain
Departement Des Sciences, Université de Nîmes University, Nimes EA7352 CHROME, Rue du Dr. G. Salan, 30021 Nîmes CEDEX 1, France
These authors equally contributed to this work.
Authors to whom correspondence should be addressed.
Received: 27 September 2017 / Revised: 24 October 2017 / Accepted: 26 October 2017 / Published: 2 November 2017
Full-Text   |   PDF [2951 KB, uploaded 6 November 2017]   |  


The electrochemical response of four natural cytotoxic thiazinoquinones isolated from the Aplidium species was studied using conventional solution-phase and solid-state techniques, based on the voltammetry of immobilized particles methodology. The interaction with O2 and electrochemically generated reactive oxygen species (ROS) was electrochemically monitored. At the same time, a molecular modeling study including density functional theory (DFT) calculations was performed in order to analyze the conformational and electronic properties of the natural thiazinoquinones, as well as those of their reduced intermediates. The obtained electrochemical and computational results were analyzed and correlated to cytotoxic activity of these compounds, highlighting some features possibly related to their mechanism of action. View Full-Text
Keywords: bioactive natural products; thiazinoquinones; electrochemistry; DFT calculations; reactive radical species; cytotoxic activity bioactive natural products; thiazinoquinones; electrochemistry; DFT calculations; reactive radical species; cytotoxic activity

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Imperatore, C.; Cimino, P.; Cebrián-Torrejón, G.; Persico, M.; Aiello, A.; Senese, M.; Fattorusso, C.; Menna, M.; Doménech-Carbó, A. Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones. Mar. Drugs 2017, 15, 335.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top