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Open AccessArticle

Sterols from the Green Alga Ulva australis

Department of Natural Medicine and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, China
Author to whom correspondence should be addressed.
Mar. Drugs 2017, 15(10), 299;
Received: 12 August 2017 / Revised: 25 September 2017 / Accepted: 27 September 2017 / Published: 28 September 2017
PDF [748 KB, uploaded 30 September 2017]


Three new sterols, (24R)-5,28-stigmastadiene-3β,24-diol-7-one (1), (24S)-5,28-stigmastadiene-3β,24-diol-7-one (2), and 24R and 24S-vinylcholesta-3β,5α,6β,24-tetraol (3), together with three known sterols (46) were isolated from the green alga Ulva australis. The structures of the new compounds (13) were elucidated through 1D and 2D nuclear magnetic resonance spectroscopy as well as mass spectrometry. Compounds 46 were identified as isofucoterol (4), 24R,28S and 24S,28R-epoxy-24-ethylcholesterol (5), and (24S)-stigmastadiene-3β,24-diol (6) on the basis of spectroscopic data analyses and comparison with those reported in the literature. Compounds 46 were isolated from U. australis for the first time. These compounds, together with the previously isolated secondary metabolites of this alga, were investigated for their inhibitory effects on human recombinant aldose reductase in vitro. Of the compounds, 24R,28S and 24S,28R-epoxy-24-ethylcholesterol (5), 1-O-palmitoyl-3-O-(6′-sulfo-α-d-quinovopyranosyl) glycerol, (2S)-1-O-palmitoyl-3-O-[α-d-galactopyranosyl(1→2)β-d-galactopyranosyl] glycerol, 4-hydroxybenzoic acid, 4-hydroxyphenylacetic acid, and 8-hydroxy-(6E)-octenoic acid weakly inhibited the enzyme, while the three new sterols, 13, were almost inactive. View Full-Text
Keywords: Chlorophyta; Ulva australis; 5,28-stigmastadiene-3β,24-diol-7-one epimers; 24-vinylcholesta-3β,5α,6β,24-tetraol Chlorophyta; Ulva australis; 5,28-stigmastadiene-3β,24-diol-7-one epimers; 24-vinylcholesta-3β,5α,6β,24-tetraol

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Li, G.-L.; Guo, W.-J.; Wang, G.-B.; Wang, R.-R.; Hou, Y.-X.; Liu, K.; Liu, Y.; Wang, W. Sterols from the Green Alga Ulva australis. Mar. Drugs 2017, 15, 299.

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