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Mar. Drugs 2015, 13(4), 1785-1797;

First Evidence that Ecklonia cava-Derived Dieckol Attenuates MCF-7 Human Breast Carcinoma Cell Migration

Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University, Chungju 380-701, Korea
Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Korea
Department of Biotechnology, Konkuk University, Chungju 380-701, Korea
Division of Sport Science, Konkuk University, Chungju, 380-701, Korea
Department of Marine Life Science, Jeju National University, Jeju 690-756, Korea
Author to whom correspondence should be addressed.
Academic Editors: Sergey A. Dyshlovoy and Friedemann Honecker
Received: 1 February 2015 / Revised: 9 March 2015 / Accepted: 18 March 2015 / Published: 30 March 2015
(This article belongs to the Collection Marine Compounds and Cancer)
Full-Text   |   PDF [677 KB, uploaded 30 March 2015]   |  


We investigated the effect of Ecklonia cava (E. cava)-derived dieckol on movement behavior and the expression of migration-related genes in MCF-7 human breast cancer cell. Phlorotannins (e.g., dieckol, 6,6′-biecko, and 2,7″-phloroglucinol-6,6′-bieckol) were purified from E. cava by using centrifugal partition chromatography. Among the phlorotannins, we found that dieckol inhibited breast cancer cell the most and was selected for further study. Radius™-well was used to assess cell migration, and dieckol (1–100 µM) was found to suppress breast cancer cell movement. Metastasis-related gene expressions were evaluated by RT-PCR and Western blot analysis. In addition, dieckol inhibited the expression of migration-related genes such as matrix metalloproteinase (MMP)-9 and vascular endothelial growth factor (VEGF). On the other hand, it stimulated the expression of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. These results suggest that dieckol exerts anti-breast cancer activity via the regulation of the expressions of metastasis-related genes, and this is the first report on the anti-breast cancer effect of dieckol. View Full-Text
Keywords: Ecklonia cava; phlorotannins; dieckol; breast cancer; migration Ecklonia cava; phlorotannins; dieckol; breast cancer; migration

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Kim, E.-K.; Tang, Y.; Kim, Y.-S.; Hwang, J.-W.; Choi, E.-J.; Lee, J.-H.; Lee, S.-H.; Jeon, Y.-J.; Park, P.-J. First Evidence that Ecklonia cava-Derived Dieckol Attenuates MCF-7 Human Breast Carcinoma Cell Migration. Mar. Drugs 2015, 13, 1785-1797.

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