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Low Molecular Weight Chitosan–Insulin Polyelectrolyte Complex: Characterization and Stability Studies
by
Zakieh I. Al-Kurdi 1,2, Babur Z. Chowdhry 2, Stephen A. Leharne 2, Mahmoud M. H. Al Omari 1
and Adnan A. Badwan 1,*
and Adnan A. Badwan 1,*
1
The Jordanian Pharmaceutical Manufacturing Company (PLC), Suwagh Subsidiary for Drug Delivery Systems, P.O. Box 94, Naor 11710, Jordan
2
Faculty of Engineering & Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME44TB, UK
*
Author to whom correspondence should be addressed.
Academic Editor: David Harding
Mar. Drugs 2015, 13(4), 1765-1784; https://doi.org/10.3390/md13041765
Received: 17 December 2014 / Revised: 28 January 2015 / Accepted: 3 February 2015 / Published: 30 March 2015
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan)
The aim of the work reported herein was to investigate the effect of various low molecular weight chitosans (LMWCs) on the stability of insulin using USP HPLC methods. Insulin was found to be stable in a polyelectrolyte complex (PEC) consisting of insulin and LMWC in the presence of a Tris-buffer at pH 6.5. In the presence of LMWC, the stability of insulin increased with decreasing molecular weight of LMWC; 13 kDa LMWC was the most efficient molecular weight for enhancing the physical and chemical stability of insulin. Solubilization of insulin-LMWC polyelectrolyte complex (I-LMWC PEC) in a reverse micelle (RM) system, administered to diabetic rats, results in an oral delivery system for insulin with acceptable bioactivity.
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MDPI and ACS Style
Al-Kurdi, Z.I.; Chowdhry, B.Z.; Leharne, S.A.; Al Omari, M.M.H.; Badwan, A.A. Low Molecular Weight Chitosan–Insulin Polyelectrolyte Complex: Characterization and Stability Studies. Mar. Drugs 2015, 13, 1765-1784.
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