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Mar. Drugs 2015, 13(1), 237-248;

New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius

Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China
These authors contributed equally to this paper.
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 26 August 2014 / Accepted: 22 December 2014 / Published: 7 January 2015
(This article belongs to the Special Issue Terpenoids of Marine Origin)
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Four new meroterpenoids (25), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 17 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities. View Full-Text
Keywords: meroterpenoid; Aspergillus flavipes; endophytic fungus meroterpenoid; Aspergillus flavipes; endophytic fungus

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Bai, Z.-Q.; Lin, X.; Wang, J.; Zhou, X.; Liu, J.; Yang, B.; Yang, X.; Liao, S.; Wang, L.; Liu, Y. New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius. Mar. Drugs 2015, 13, 237-248.

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