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Mar. Drugs 2014, 12(12), 5856-5863;

Rumphellaoic Acid A, a Novel Sesquiterpenoid from the Formosan Gorgonian Coral Rumphella antipathies

Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Marine Biology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 9 September 2014 / Revised: 4 November 2014 / Accepted: 21 November 2014 / Published: 4 December 2014
(This article belongs to the Special Issue Terpenoids of Marine Origin)
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A novel sesquiterpenoid, rumphellaoic acid A (1), was isolated from the gorgonian coral Rumphella antipathies, and was found to possess a carbon skeleton that was obtained for the first time from a natural sources. The structure of 1 was elucidated by spectroscopic methods and this compound and was found to exert a moderate inhibitory effect on the release of elastase by human neutrophils. View Full-Text
Keywords: Rumphella antipathies; gorgonian; rumphellaoic acid; sesquiterpenoid; elastase Rumphella antipathies; gorgonian; rumphellaoic acid; sesquiterpenoid; elastase

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Chung, H.-M.; Wang, W.-H.; Hwang, T.-L.; Fang, L.-S.; Wen, Z.-H.; Chen, J.-J.; Wu, Y.-C.; Sung, P.-J. Rumphellaoic Acid A, a Novel Sesquiterpenoid from the Formosan Gorgonian Coral Rumphella antipathies. Mar. Drugs 2014, 12, 5856-5863.

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