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Article

Extraintestinal Manifestations in Inflammatory Bowel Disease: A Retrospective Observational Study in a Peruvian Tertiary Hospital

by
Miguel A. Arce-Huamani
1,*,
Alvaro N. Sicos-Hancari
1,
Maria D. Vallejo-Jaime
1,
Ayde M. Quispe-Oncebay
1,
Irene Cárdenas-Vela
2,
Jacqueline Abad-Núñez
2,
Luis Cervera-Caballero
2 and
Ofelia Castillo-Contreras
2
1
Research for Evidence, Care, and Public Health, Programa Academico de Medicina Humana, Facultad de Ciencias de la Salud, Universidad Privada Norbert Wiener, Lima 15046, Peru
2
Hospital Nacional Edgardo Rebagliati Martins, Lima 15046, Peru
*
Author to whom correspondence should be addressed.
Medicina 2026, 62(8), 1471; https://doi.org/10.3390/medicina62081471
Submission received: 20 June 2026 / Revised: 13 July 2026 / Accepted: 15 July 2026 / Published: 29 July 2026
(This article belongs to the Section Gastroenterology & Hepatology)
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Abstract

Background and Objectives: Extraintestinal manifestations (EIMs) are clinically relevant components of inflammatory bowel disease (IBD), but real-world data from Latin American referral settings remain limited. This study aimed to estimate the frequency and pattern of documented EIMs and identify associated factors in a Peruvian tertiary-care cohort. Materials and Methods: We conducted a retrospective analytical study at the Gastroenterology Service of Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru. Adults with confirmed IBD attended between April 2020 and February 2025 were included (n = 162). EIMs were defined as documented articular, dermatologic, or ocular involvement. Crude and adjusted odds ratios (ORs and aORs) with 95% confidence intervals (CIs) were estimated using logistic regression. Results: The mean age was 50.6 ± 18.3 years, 54.9% were female, and 71.0% had ulcerative colitis. Overall, 16.7% of patients had at least one documented predefined EIM. Articular involvement was the most frequent manifestation (11.7%), whereas dermatologic and ocular manifestations each accounted for 2.5%. In the exploratory adjusted model, the harmonized Montreal category 3 retained a statistically significant association with documented EIMs (aOR 3.12, 95% CI 1.19–8.18; p = 0.021). Conclusions: In this Peruvian tertiary IBD cohort, documented EIMs affected a meaningful minority of patients and were predominantly articular. The harmonized Montreal category 3 was associated with documented EIMs and may help flag patients for more targeted systemic and multidisciplinary assessment, although this exploratory finding requires external validation.
Keywords: inflammatory bowel disease; extraintestinal manifestations; ulcerative colitis; Crohn’s disease; Montreal classification inflammatory bowel disease; extraintestinal manifestations; ulcerative colitis; Crohn’s disease; Montreal classification

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MDPI and ACS Style

Arce-Huamani, M.A.; Sicos-Hancari, A.N.; Vallejo-Jaime, M.D.; Quispe-Oncebay, A.M.; Cárdenas-Vela, I.; Abad-Núñez, J.; Cervera-Caballero, L.; Castillo-Contreras, O. Extraintestinal Manifestations in Inflammatory Bowel Disease: A Retrospective Observational Study in a Peruvian Tertiary Hospital. Medicina 2026, 62, 1471. https://doi.org/10.3390/medicina62081471

AMA Style

Arce-Huamani MA, Sicos-Hancari AN, Vallejo-Jaime MD, Quispe-Oncebay AM, Cárdenas-Vela I, Abad-Núñez J, Cervera-Caballero L, Castillo-Contreras O. Extraintestinal Manifestations in Inflammatory Bowel Disease: A Retrospective Observational Study in a Peruvian Tertiary Hospital. Medicina. 2026; 62(8):1471. https://doi.org/10.3390/medicina62081471

Chicago/Turabian Style

Arce-Huamani, Miguel A., Alvaro N. Sicos-Hancari, Maria D. Vallejo-Jaime, Ayde M. Quispe-Oncebay, Irene Cárdenas-Vela, Jacqueline Abad-Núñez, Luis Cervera-Caballero, and Ofelia Castillo-Contreras. 2026. "Extraintestinal Manifestations in Inflammatory Bowel Disease: A Retrospective Observational Study in a Peruvian Tertiary Hospital" Medicina 62, no. 8: 1471. https://doi.org/10.3390/medicina62081471

APA Style

Arce-Huamani, M. A., Sicos-Hancari, A. N., Vallejo-Jaime, M. D., Quispe-Oncebay, A. M., Cárdenas-Vela, I., Abad-Núñez, J., Cervera-Caballero, L., & Castillo-Contreras, O. (2026). Extraintestinal Manifestations in Inflammatory Bowel Disease: A Retrospective Observational Study in a Peruvian Tertiary Hospital. Medicina, 62(8), 1471. https://doi.org/10.3390/medicina62081471

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