Assessment of Visual Acuity and Stereopsis in Older Adults: A Comparison Between a Screening Application and Clinical Standards—A Feasibility Study
Abstract
1. Introduction
- To compare VA and SV measurements with the index and the clinical reference methods, namely the ETDRS-style Landolt C chart for VA and the TNO stereotest for SV, to assess how accurately the index method identifies visual impairment in individuals over 60 years of age.
- To examine the test–retest reliability of the index method for VA and SV in an elderly population.
- To evaluate the diagnostic performance of the index stereotests and define optimal cutoffs for detecting impaired stereopsis in an aging population.
2. Materials and Methods
2.1. Participants
2.2. Testing Procedures
2.3. Visual Acuity Tests
2.4. Stereovision Tests
2.5. Statistical Analysis
- VA outcomes: Cross-sectional descriptive outcomes are reported for both methods. Agreement between the tablet-based index test and the reference was evaluated with Bland–Altman method by calculating mean difference (bias) and 95% limits of agree-ment (LoA). A paired t-test was used to examine whether a systematic difference existed between the two methods. For comparability, VA values better than 0 logMAR obtained with the index method were truncated at 0, and the analysis focused on acuity values worse than 0 logMAR. This range included 130 of 189 measurements, and reflects the age and typical visual status of the study population.
- SV outcomes: For the primary analysis, a TNO disparity level of 480″ was selected as the reference threshold, as it corresponds to the upper limit of stereoacuity typically reported in older adults [24,25,26] and showed the best agreement with index test results in our da-taset (see Appendix A). For the index stereotests (SRDS and DRDS), performance was evaluated using a pass–fail criterion defined as correctly identifying at least 5 out of 10 stimuli. This cutoff was selected based on a Bernoulli probability model (p < 0.01), as the probability of achieving ≥5 correct responses by random guessing in a 10-trial format is below 1%.Diagnostic performance of the index tests relative to the TNO-based classification was evaluated using Receiver Operating Characteristic (ROC) analysis, with pass–fail cutoffs optimized for sensitivity. The area under the ROC curve (AUC) and corresponding confidence intervals were calculated.
3. Results
3.1. Test–Retest Group
3.1.1. Visual Acuity
3.1.2. Stereovision
| (A) | ||||||
VA Test | Bias (95% CI) | SD (Bias) | Limits of Agreement (Lower; Upper, 95% CI) | Mean (SD) for Test and Retest, Paired Sample t-Test: p-Value, t-Stat | ICC (95% CI) | ICC, p-Value |
| Reference method | 0.048 (0.030–0.065) | 0.075 | −0.10 (−0.13–−0.068); 0.19 (0.16–0.23) | −0.029 (±0.21); −0.076 (±0.20) <0.001 (5.37) | 0.90 (0.85–0.94) | <0.001 |
| Index method | 0.022 (−0.0036–0.047) | 0.107 | −0.19 (−0.23–−0.144); 0.23 (0.19–0.28) | −0.14 (±0.18); −0.16 (±0.15) 0.092 | 0.79 (0.68–0.86) | <0.001 |
| (B) | ||||||
| Test | Session 1 Summary | Session 2 Summary | Identical Classification n (%) | Cohen’s κ (95% CI) | ||
| Reference method (TNO stereotest) | 95″ range: 60–480″; 95% CI: 53.46–136.54 | 82.5″ range: 60–240″ 95% CI: 55.76–109.24 | 24/24 (100%) | 1 | ||
| Index method SRDS | 9.7/10 stimuli | 9.4/10 stimuli | 24/24 (100%) | 1 | ||
| Index methodDRDS | 9.0/10 stimuli | 8.8/10 stimuli | 23/24 (95.9%) | 0.647 (0.013 1.00) | ||
3.2. Clinical Cross-Sectional Group
3.2.1. Visual Acuity
3.2.2. Stereovision
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
| ″ | Second of Arc, Arcsecond, Arcsec |
| AUC | Area Under the Curve |
| Best PEST | Best Parameter Estimation by Sequential Testing |
| DRDS | Dynamic Random Dot Stereogram |
| ETDRS | Early Treatment Diabetic Retinopathy Study |
| LoA | Limits of Agreement |
| NA | Not Applicable |
| OR | Odds Ratio |
| ROC | Receiver Operating Characteristic |
| RDS | Random Dot Stereogram |
| SRDS | Static Random Dot Stereogram |
| SV | Stereovision |
| VA | Visual Acuity |
Appendix A
Determination of the Optimal TNO Reference Threshold
| TNO Threshold | TNO | SRDS (Pass/Fail) | DRDS (Pass/Fail) | |
|---|---|---|---|---|
| 60′ | Pass | 63 | 54/9 | 46/17 |
| Fail | 56 | 31/25 | 26/30 | |
| AUC (95%CI) | - | 0.70 (0.61–0.78) | 0.68 (0.59–0.76) | |
| 120′ | Pass | 78 | 69/9 | 59/19 |
| Fail | 41 | 16/25 | 13/28 | |
| AUC (95%CI) | - | 0.78 (0.69–0.85) | 0.74 (0.66–0.82) | |
| 240′ | Pass | 94 | 78/16 | 68/26 |
| Fail | 25 | 7/18 | 4/21 | |
| AUC (95%CI) | - | 0.80 (0.72–0.87) | 0.82 (0.74–0.88) | |
| 480′ | Pass | 102 | 82/20 | 71/31 |
| Fail | 17 | 3/14 | 1/16 | |
| AUC (95%CI) | - | 0.87 (0.80–0.93) | 0.84 (0.76–0.90) | |
| 1980′ | Pass | 112 | 82/30 | 71/41 |
| Fail | 7 | 3/4 | 1/6 | |
| AUC (95%CI) | - | 0.75 (0.67–0.83) | 0.79 (0.70–0.86) | |
| NIL stereopsis TNO | 7 | 3/4 | 1/6 | |
| NIL stereopsis SRDS | 29/4 | 33 | 33 | |
| NIL stereopsis DRDS | 41/6 | 14/33 | 47 |
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| Number of Patients | Mean Age (yrs) | Female (%) | Mean VA (logMAR) | Stereoacuity (arcmin) | Inclusion Criteria | Exclusion Criteria | |
|---|---|---|---|---|---|---|---|
| Test–retest group | 24 | 65.96 SD = ±5.94 | 45.8 | −0.052(SD: ±0.20) | 95″ (95% CI: 53.46–136.54) |
|
|
| Clinical cross-sectional group | 135 | 72.73 SD = ±6.95 | 70 | 0.19 (SD: ±0.20) | 342.15″ (95% CI: 237.33–446.97) |
| Test Name | Stimuli | Channel Separation | Type of Test | Manufacturer | Dot Size, Viewing Distance (meters) | Luminance of Background (cd/m2) | Possible Results | Cutoff | Nr. of Participants (Test–Retest and Clinical Cross-Sectional Groups) |
|---|---|---|---|---|---|---|---|---|---|
| Visual acuity testing | |||||||||
| Index VA method | Landolt C | N/A | high contrast optotype | EuvisionTab® v0.32, Euvision Ltd., Pécs, Hungary | N/A, 5.0 | 165 | 1.3 to −0.44 logMAR | Best PEST: steepest part of the psychometric function | 24 and 63 |
| Reference VA method (ETDRS-style) | Landolt C | N/A | high contrast optotype | Visionix, VX 22-LP Chart display, Visionix Ltd., Jerusalem, Israel | N/A, 5.0 | 207 | 1.3 to −0.4 logMAR | 3 /5 correct | 24 and 63 |
| Stereovision testing | |||||||||
| Index SV method | Snellen E presented in SRDS and DRDS | anaglyphic | global, random dot | EuvisionTab® v0.32, Euvision Ltd., Pécs, Hungary | 420″ 0.25–0.30 | N/A | 0–10 out of 10 presentations | 5/10 5/10 correct | 24 and 119 |
| Reference SV method | Plates V and VI, “pancake” | anaglyphic | global, random dot | Lameris Ootech B.V., Utrecht, The Netherlands | 108″ 0.40 | N/A | Nil stereopsis, 1800″ 480″ 240″ 120″ 60″ | 480″ | 24 and 131 |
| VA Range (logMAR) | N. of Tests | Bias (95% CI) | Lower LoA (95% CI) | Upper LoA (95% CI) | Mean (SD) Reference and Index Test, Paired t-Test |
|---|---|---|---|---|---|
| All ranges | 189 | 0.022 (0.0057 to 0.039) | −0.206 (−0.24 to −0.18) | 0.25 (0.22 to 0.28) | 0.19 (0.20); 0.17 (0.18) p = 0.0088 |
| Poor: reference ≥ 0.3 | 55 | 0.092 (0.049 to 0.14) | −0.22 (−0.29 to 0.15) | 0.41 (0.33 to 0.48) | 0.44 (0.18); 0.35 (0.20) p = 0.0001 |
| Intermediate: 0 < reference < 0.3 | 75 | −0.0061 (−0.019 to 0.0072) | −0.16 (−0.18 to 0.14) | 0.15 (0.12 to 0.17) | 0.15 (0.056); 0.14 (0.1021) p = 0.44 |
| Good VA reference = 0 | 59 | 0.047 (0.017 to 0.076) | −0.17 (−0.23 to −0.12) | 0.27 (0.22 to 0.32) | 0.00 (0.0); 0.024 (0.049) p = 0.0003 |
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Wiegand, D.; Mikó-Baráth, E.; Telkes, I.; Patczai, B.; Csutak, A.; Nemes, V.A. Assessment of Visual Acuity and Stereopsis in Older Adults: A Comparison Between a Screening Application and Clinical Standards—A Feasibility Study. Medicina 2026, 62, 517. https://doi.org/10.3390/medicina62030517
Wiegand D, Mikó-Baráth E, Telkes I, Patczai B, Csutak A, Nemes VA. Assessment of Visual Acuity and Stereopsis in Older Adults: A Comparison Between a Screening Application and Clinical Standards—A Feasibility Study. Medicina. 2026; 62(3):517. https://doi.org/10.3390/medicina62030517
Chicago/Turabian StyleWiegand, Dorottya, Eszter Mikó-Baráth, Ildikó Telkes, Balázs Patczai, Adrienne Csutak, and Vanda Agnes Nemes. 2026. "Assessment of Visual Acuity and Stereopsis in Older Adults: A Comparison Between a Screening Application and Clinical Standards—A Feasibility Study" Medicina 62, no. 3: 517. https://doi.org/10.3390/medicina62030517
APA StyleWiegand, D., Mikó-Baráth, E., Telkes, I., Patczai, B., Csutak, A., & Nemes, V. A. (2026). Assessment of Visual Acuity and Stereopsis in Older Adults: A Comparison Between a Screening Application and Clinical Standards—A Feasibility Study. Medicina, 62(3), 517. https://doi.org/10.3390/medicina62030517

