Comparison of Effects of Chorionic Gonadotropin Alfa and Anastrozole on Sperm Retrieval Rate in Patients with Non-Mosaic Klinefelter Syndrome Following Microdissection Testicular Sperm Extraction
Abstract
1. Introduction
2. Materials and Methods
3. Statistical Analysis
4. Results
5. Discussion
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Min–Max | Median | Mean ± SD/n-% | ||
---|---|---|---|---|
Age | 21.0–43.0 | 29.0 | 29.1 ± 4.9 | |
Infertility duration | 1.0–17.0 | 5.0 | 5.8 ± 3.3 | |
FSH | ||||
Pre-treatment | 1.1–90.6 | 43.3 | 45.8 ± 17.7 | |
Post-treatment | 2.7–104.6 | 37.0 | 39.4 ± 21.3 | |
LH | ||||
Pre-treatment | 0.6–39.0 | 23.6 | 23.5 ± 8.4 | |
Post-treatment | 1.0–43.7 | 20.0 | 20.8 ± 10.2 | |
Testosterone | ||||
Pre-treatment | 38.4–523.9 | 152.0 | 189.6 ± 103.1 | |
Post-treatment | 20.0–710.2 | 260.9 | 279.9 ± 132.6 | |
Prolactin | ||||
Pre-treatment | 4.7–19.8 | 9.4 | 10.0 ± 3.2 | |
Post-treatment | 4.2–32.6 | 9.8 | 10.3 ± 4.8 | |
Estradiol | ||||
Pre-treatment | 7.5–58.6 | 31.3 | 30.3 ± 11.9 | |
Post-treatment | 11.8–94.4 | 30.6 | 35.4 ± 17.5 | |
Testicular volume (cc) | 10.0–23.0 | 16.0 | 15.4 ± 3.4 | |
Treatment | Choriogonadotropin | 21 48.8% | ||
Anastrazole | 22 51.2% | |||
TESE | (−) | 29 67.4% | ||
(+) | 14 32.6% |
Pre-Treatment | Post-Treatment | p | |||
---|---|---|---|---|---|
Mean ± SD | Median | Mean ± SD | Median | ||
FSH | 45.8 ± 17.7 | 43.3 | 39.4 ± 21.3 | 37.0 | 0.080 W |
LH | 23.5 ± 8.4 | 23.6 | 20.8 ± 10.2 | 20.0 | 0.051 P |
Testosterone | 189.6 ± 103.1 | 152.0 | 279.9 ± 132.6 | 260.9 | 0.000 W |
Prolactin | 10.0 ± 3.2 | 9.4 | 10.3 ± 4.8 | 9.8 | 0.822 W |
Estradiol | 30.3 ± 11.9 | 31.3 | 35.4 ± 17.5 | 30.6 | 0.231 P |
TESE (−) | TESE (+) | p | ||||
---|---|---|---|---|---|---|
Mean ± SD/n-% | Median | Mean ± SD/n-% | Median | |||
Age | 29.4 ± 5.3 | 29.0 | 28.6 ± 4.0 | 27.5 | 0.601 t | |
Infertility duration | 5.8 ± 3.7 | 5.0 | 5.7 ± 2.3 | 5.5 | 0.824 m | |
FSH | ||||||
Pre-treatment | 47.1 ± 19.3 | 43.7 | 43.0 ± 14.2 | 39.9 | 0.437 m | |
Post-treatment | 40.3 ± 21.7 | 37.0 | 37.6 ± 21.2 | 36.4 | 0.766 m | |
Intra-group change p | 0.082 W | 0.593 W | ||||
LH | ||||||
Pre-treatment | 24.0 ± 9.0 | 23.4 | 22.5 ± 7.2 | 24.1 | 0.590 t | |
Post-treatment | 21.1 ± 10.4 | 20.1 | 20.2 ± 10.2 | 19.8 | 0.787 t | |
Intra-group change p | 0.088 P | 0.361 P | ||||
Testosterone | ||||||
Pre-treatment | 196.4 ± 109.3 | 170.1 | 175.4 ± 91.2 | 141.3 | 0.452 m | |
Post-treatment | 278.0 ± 143.6 | 255.0 | 283.8 ± 111.1 | 275.4 | 0.437 m | |
Intra-group change p | 0.002 W | 0.004 W | ||||
Prolactin | ||||||
Pre-treatment | 10.2 ± 3.5 | 9.8 | 9.4 ± 2.7 | 9.0 | 0.659 m | |
Post-treatment | 10.2 ± 5.0 | 9.8 | 10.5 ± 4.6 | 9.0 | 0.948 m | |
Intra-group change p | 0.417 W | 0.279 W | ||||
Estradiol | ||||||
Pre-treatment | 30.5 ± 12.3 | 31.3 | 29.9 ± 11.7 | 31.5 | 0.959 t | |
Post-treatment | 35.3 ± 19.4 | 30.0 | 35.8 ± 13.5 | 36.3 | 0.613 t | |
Intra-group change p | 0.339 W | 0.552 W | ||||
Testicular volume (cc) | 15.2 ± 3.5 | 15.0 | 15.9 ± 3.3 | 16.0 | 0.539 m | |
Treatment | Choriogonadotropin | 17 58.6% | 4 28.6% | 0.065 | ||
Anastrozole | 12 41.4% | 10 71.4% |
Choriogonadotropin Alfa (n = 21) | Anastrozole (n = 22) | p | ||||
---|---|---|---|---|---|---|
Mean ± SD/n-% | Median | Mean ± SD/n-% | Median | |||
Age | 29.6 ± 5.7 | 29.0 | 28.7 ± 4.0 | 28.5 | 0.535 t | |
Infertility duration | 6.3 ± 3.6 | 5.0 | 5.3 ± 2.9 | 5.0 | 0.391 m | |
FSH | ||||||
Pre-treatment | 45.4 ± 19.5 | 43.7 | 46.1 ± 16.4 | 40.7 | 0.846 m | |
Post-treatment | 33.7 ± 21.7 | 30.8 | 44.9 ± 19.9 | 41.0 | 0.068 m | |
Intra-group change p | 0.007 W | 0.385 W | ||||
LH | ||||||
Pre-treatment | 24.2 ± 9.1 | 24.5 | 22.8 ± 7.7 | 22.5 | 0.584 t | |
Post-treatment | 19.6 ± 12.4 | 18.9 | 22.0 ± 7.7 | 21.0 | 0.440 t | |
Intra-group change p | 0.050 P | 0.591 P | ||||
Testosterone | ||||||
Pre-treatment | 158.8 ± 83.1 | 143.1 | 218.9 ± 113.4 | 183.5 | 0.068 m | |
Post-treatment | 260.6 ± 142.3 | 243.7 | 298.3 ± 123.1 | 278.5 | 0.120 m | |
Intra-group change p | 0.003 W | 0.001 W | ||||
Prolactin | ||||||
Pre-treatment | 8.9 ± 2.4 | 9.3 | 11.0 ± 3.6 | 11.0 | 0.063 m | |
Post-treatment | 10.1 ± 5.7 | 9.2 | 10.5 ± 4.0 | 10.0 | 0.552 m | |
Intra-group change p | 0.664 W | 0.532 W | ||||
Estradiol | ||||||
Pre-treatment | 29.6 ± 10.7 | 31.5 | 31.0 ± 13.2 | 31.1 | 0.717 t | |
Post-treatment | 41.2 ± 19.4 | 40.9 | 29.9 ± 13.7 | 27.7 | 0.032 t | |
Intra-group change p | 0.018 P | 0.602 P | ||||
Testicular volume (cc) | 13.8 ± 3.2 | 14.0 | 16.9 ± 2.8 | 18.0 | 0.001 m | |
TESE | (−) | 17 81.0% | 12 54.5% | 0.065 | ||
(+) | 4 19.0% | 10 45.5% |
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Pelit, E.S.; Danacıoğlu, Y.O.; Katı, B. Comparison of Effects of Chorionic Gonadotropin Alfa and Anastrozole on Sperm Retrieval Rate in Patients with Non-Mosaic Klinefelter Syndrome Following Microdissection Testicular Sperm Extraction. Medicina 2025, 61, 467. https://doi.org/10.3390/medicina61030467
Pelit ES, Danacıoğlu YO, Katı B. Comparison of Effects of Chorionic Gonadotropin Alfa and Anastrozole on Sperm Retrieval Rate in Patients with Non-Mosaic Klinefelter Syndrome Following Microdissection Testicular Sperm Extraction. Medicina. 2025; 61(3):467. https://doi.org/10.3390/medicina61030467
Chicago/Turabian StylePelit, Eyyup Sabri, Yavuz Onur Danacıoğlu, and Bülent Katı. 2025. "Comparison of Effects of Chorionic Gonadotropin Alfa and Anastrozole on Sperm Retrieval Rate in Patients with Non-Mosaic Klinefelter Syndrome Following Microdissection Testicular Sperm Extraction" Medicina 61, no. 3: 467. https://doi.org/10.3390/medicina61030467
APA StylePelit, E. S., Danacıoğlu, Y. O., & Katı, B. (2025). Comparison of Effects of Chorionic Gonadotropin Alfa and Anastrozole on Sperm Retrieval Rate in Patients with Non-Mosaic Klinefelter Syndrome Following Microdissection Testicular Sperm Extraction. Medicina, 61(3), 467. https://doi.org/10.3390/medicina61030467