Evaluation of a Hybrid CNN Model for Automatic Detection of Malignant and Benign Lesions

Background and Objectives: Stratifying thyroid nodules according to malignancy risk is a crucial step in early diagnosis and patient care. Recently, deep learning techniques have emerged as powerful tools for medical diagnostics, particularly with convolutional neural networks (CNNs) applied to medical image classification. This study aimed to develop a new hybrid CNN model for classifying thyroid nodules using the TN5000 ultrasound image dataset. Materials and Methods: The TN5000 dataset includes 5000 ultrasound images, with 3572 malignant and 1428 benign nodules. To address the issue of class imbalance, the researchers applied an R-based anomaly data augmentation method and a GAN-based technique (G-RAN) to generate synthetic benign images, resulting in a balanced dataset for training. The model architecture was built on a pre-trained EfficientNet-B3 backbone, further enhanced with squeeze-and-excitation (SE) blocks and residual refinement modules to improve feature extraction. The task was to classify malignant nodules (labeled 1) and benign nodules (labeled 0). Results: The proposed hybrid CNN achieved strong performance, with an accuracy of 89.73%, sensitivity of 90.01%, precision of 88.23%, and an F1-score of 88.85%. The total training time was 42 min. Conclusions: The findings demonstrate that the proposed hybrid CNN model is a promising tool for thyroid nodule classification on ultrasound images. Its high diagnostic accuracy suggests that it could serve as a reliable decision-support system for clinicians, improving consistency in diagnosis and reducing human error. Future work will focus on clinical validation, explainability of the model’s decision-making process, and strategies for integration into routine hospital workflows.