The MARVIN Hypothesis: Linking Unhealthy Lifestyles to Intracranial Aneurysm Rupture Risk and Clinical Prognosis
Abstract
1. Introduction
2. Materials and Methods
2.1. Data Acquisition
2.2. Statistical Analysis
3. Results
3.1. Cohort Overview
3.1.1. Rupture Analysis
3.1.2. Outcome Analysis
3.2. Analysis of Clinical Outcome and Rupture
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameter | Rupture Analysis (n = 225) | Outcome Analysis (n = 221) |
---|---|---|
Sex | 75 male; 150 female | 76 male; 145 female |
Age at diagnosis (mean) | 54.8 (±12.5) years | 54.9 (±12.5) years |
Arterial hypertension | 165 (73.3%) | 163 (73.8%) |
Diabetes mellitus Type 2 | 29 (13%) | 29 (13.1%) |
Hypercholesterolemia | 45 (20%) | 45 (20.4%) |
Vascular diseases | 26 (11.6%) | 26 (11.8%) |
Nicotine abuse | 141 (62.7%) | 138 (62.4%) |
Alcohol abuse | 36 (16%) | 36 (16.3%) |
Obesity | 67 (30%) | 64 (29.0%) |
Ruptured aneurysms | 154 (68.4%) | 152 (68.8%) |
Multiple aneurysms | 88 (39.1%) | 87 (39.4%) |
Aneurysm size (mm, mean) | 7.4 (±3.0) | 7.4 (±3.0) |
Aneurysm localization | ||
ACA | 2 (0.9%) | 2 (0.8%) |
ACOM | 105 (46.7%) | 103 (46.6%) |
Pericallosal artery | 2 (0.9%) | 2 (0.8%) |
MCA | 45 (20%) | 45 (20.4%) |
ICA | 28 (12.4%) | 27 (12.2%) |
PCOM | 3 (1.3%) | 3 (1.4%) |
Anterior choroidal artery | 2 (0.9%) | 2 (0.8%) |
Basilar artery | 25 (11.1%) | 24 (10.9%) |
Vertebral artery | 3 (1.3%) | 3 (1.4%) |
PICA | 7 (3.1%) | 7 (3.2%) |
SCA | 3 (1.3%) | 3 (1.4%) |
WFNS score | ||
1 | 86 (55.8%) | 86 (56.6%) |
2 | 23 (14.9%) | 23 (15.1%) |
3 | 4 (2.6%) | 4 (2.6%) |
4 | 21 (13.6%) | 21 (14.8%) |
5 | 18 (11.7%) | 18 (11.8%) |
No information | 2 (1.3%) | 0 (0%) |
Fisher grade | ||
1 | 4 (2.6%) | 4 (2.6%) |
2 | 5 (3.3%) | 5 (3.3%) |
3 | 55 (35.7%) | 54 (35.5%) |
4 | 89 (55.8%) | 89 (56.6%) |
No information | 1 (0.7%) | 0 (0%) |
Variable 1 | Variable 2 | p-Value | Odds Ratio |
---|---|---|---|
Hypertension | Nicotine abuse | 0.034 | 0.5 |
Hypertension | Hypercholesterolemia | 0.001 | 6.6 |
Hypertension | Obesity | 0.002 | 3.6 |
Hypertension | Vascular diseases | 0.011 | 10.5 |
Hypertension | Diabetes | 0.059 | 3.5 |
Nicotine abuse | Alcohol abuse | 0.003 | 4.4 |
Hypercholesterolemia | Vascular diseases | 1.86 × 10−6 | 7.4 |
Obesity | Diabetes | 0.033 | 2.5 |
Variable | Univariate Analysis (p-Value) | Multivariate Analysis (p-Value) |
---|---|---|
Age | 0.003 | <10⁻⁵ |
Sex | 0.6 | - |
WFNS Score | <0.001 | <10⁻⁶ |
Hypertension | 0.6 | - |
Nicotine abuse | 0.8 | - |
Diabetes | 0.1 | - |
Hypercholesterolemia | 0.4 | - |
Obesity | 0.1 | - |
Alcohol abuse | 0.7 | - |
Vascular diseases | 0.5 | - |
Variable | Univariate Analysis (p-Value) | Multivariate Analysis (p-Value) |
---|---|---|
Age | 0.001 | 0.004 |
Sex | 0.3 | - |
Hypertension | 0.5 | - |
Nicotine abuse | 0.3 | - |
Diabetes | 0.7 | - |
Hypercholesterolemia | 0.09 | - |
Obesity | 1 | - |
Alcohol abuse | 0.9 | - |
Vascular diseases | 0.0002 | 0.001 |
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© 2024 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Swiatek, V.M.; Fischer, I.; Khajuria, R.; Amini, A.; Steinkusch, H.; Rashidi, A.; Stein, K.-P.; Dumitru, C.A.; Sandalcioglu, I.E.; Neyazi, B. The MARVIN Hypothesis: Linking Unhealthy Lifestyles to Intracranial Aneurysm Rupture Risk and Clinical Prognosis. Medicina 2024, 60, 1813. https://doi.org/10.3390/medicina60111813
Swiatek VM, Fischer I, Khajuria R, Amini A, Steinkusch H, Rashidi A, Stein K-P, Dumitru CA, Sandalcioglu IE, Neyazi B. The MARVIN Hypothesis: Linking Unhealthy Lifestyles to Intracranial Aneurysm Rupture Risk and Clinical Prognosis. Medicina. 2024; 60(11):1813. https://doi.org/10.3390/medicina60111813
Chicago/Turabian StyleSwiatek, Vanessa M., Igor Fischer, Rajiv Khajuria, Amir Amini, Hannah Steinkusch, Ali Rashidi, Klaus-Peter Stein, Claudia A. Dumitru, I. Erol Sandalcioglu, and Belal Neyazi. 2024. "The MARVIN Hypothesis: Linking Unhealthy Lifestyles to Intracranial Aneurysm Rupture Risk and Clinical Prognosis" Medicina 60, no. 11: 1813. https://doi.org/10.3390/medicina60111813
APA StyleSwiatek, V. M., Fischer, I., Khajuria, R., Amini, A., Steinkusch, H., Rashidi, A., Stein, K.-P., Dumitru, C. A., Sandalcioglu, I. E., & Neyazi, B. (2024). The MARVIN Hypothesis: Linking Unhealthy Lifestyles to Intracranial Aneurysm Rupture Risk and Clinical Prognosis. Medicina, 60(11), 1813. https://doi.org/10.3390/medicina60111813