Epithelial Ovarian Cancer: A Five Year Review
, Kalliopi Dampala 1, Christos Anthoulakis 1, Evangelos G. Papanikolaou 2, Ioannis Tentas 3, Georgios Dragoutsos 4, Nikolaos Machairiotis 5, Paul Zarogoulidis 6,*, Aristeidis Ioannidis 7, Dimitris Matthaios 8, Eleni I. Perdikouri 9, Dimitrios Giannakidis 10, Chrysanthi Sardeli 11, Stamatios Petousis 12, Panagoula Oikonomou 13, Christina Nikolaou 13, Charalampos Charalampidis 14 and Konstantinos Sapalidis 6
Round 1
Reviewer 1 Report
The manuscript included much information regarding epithelial ovarian cancer morphology, molecular biology, and treatment options. The content was presented in long paragraphs and it is difficult to understand various points, with or without context. If break the content into multiple paragraphs, it would be easier to understand.
Figure 2 and table 1 are redundant; column #5 has no title.
Figure 3 demonstrated ongoing clinical trials for clear cell carcinoma, but there was no context.
Minor editing in language is needed.
Author Response
The manuscript included much information regarding epithelial ovarian cancer morphology, molecular biology, and treatment options. The content was presented in long paragraphs and it is difficult to understand various points, with or without context. If break the content into multiple paragraphs, it would be easier to understand.
Thank you for your comment
Answer
We have divided the manuscript into more paragraphs
Figure 2 and table 1 are redundant; column #5 has no title.
Thank you for your comment
Answer
We have removed Figure number 2 and Table 1 as indicated by you.
Figure 3 demonstrated ongoing clinical trials for clear cell carcinoma, but there was no context.
Thank you for your comment
Answer
We do not have any additional data regarding these trials and that is why we did not include more information
Author Response File: 
Author Response.pdf
Reviewer 2 Report
Main contents and dicussion is not associated well.
Main contents describes cancer stem cell and genetic alterations and anothers.
But discussion describes only about chemotherapy.
In my opinion, discussion may include and summarize main contents.
In discussion, 'Oss' must be corrected and full name of 'OR' described.
Author Response
Reviewer 2
Comments and Suggestions for Authors
Main contents and dicussion is not associated well.
Main contents describes cancer stem cell and genetic alterations and anothers.
But discussion describes only about chemotherapy.
In my opinion, discussion may include and summarize main contents.
Thank you for your comments
Answer
We have divided the manuscript into more paragraphs as indicated by reviewer number 1 and we have erased figure 2 and Table 1. As indicated by reviewer number 1
We have also added a summary in the discussion section as indicated by you
Comments on the Quality of English Language
In discussion, 'Oss' must be corrected and full name of 'OR' described.
The `Oss` has been corrected to `OS`
And `OR` has been corrected to `Overall Survival`
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
In "Current data based on studies", many aspects of biology and therapy were discussed. However, the topics were not closely related and were grouped in one paragraph. Recommend break the contents into more paragraphs.
Minor issues, such as punctuations.
Author Response
Reviewer 1
In "Current data based on studies", many aspects of biology and therapy were discussed. However, the topics were not closely related and were grouped in one paragraph. Recommend break the contents into more paragraphs.
Thank you for your comment
Answer
We chose to divide the Paragraph into studies related with conventional treatment and biological treatment
Comments on the Quality of English Language
Minor issues, such as punctuations.
Thank you for your comment
Answer
We performed corrections where necessary
Author Response File: 
Author Response.docx
Reviewer 2 Report
Your revison is suitable to accept.
Author Response
Reviewer 2
Comments and Suggestions for Authors
Your revison is suitable to accept.
Thank you for your comment
Answer
Thank you
Author Response File: Author Response.docx
