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Volume 59
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10.3390/medicina59030580
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Article

Does the Polydimethylsiloxane Urethral Injection (Macroplastique®) Improve Sexual Function in Women, in Fertile Age, Affected by Stress Urinary Incontinence?

by
Maurizio Serati
1,*,†,
Andrea Braga
2,
Chiara Scancarello
1,
Andrea De Rosa
1,
Matteo Frigerio
3,
Yoav Baruch
4,
Marco Torella
5,
Stefano Salvatore
6 and
Alessandro Ferdinando Ruffolo
6
1
Department of Obstetrics and Gynecology, Del Ponte Hospital, University of Insubria, 21100 Varese, Italy
2
Department of Obstetrics and Gynecology, EOC-Beata Vergine Hospital, 6850 Mendrisio, Switzerland
3
ASST Monza, Ospedale San Gerardo, 20900 Monza, Italy
4
Urogynecology and Pelvic Floor Unit, Department of Obstetrics and Gynecology, Tel Aviv Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
5
Department of Obstetrics and Gynecology, Second Faculty, 80100 Naples, Italy
6
Obstetrics and Gynecology Unit, IRCCS San Raffaele Hospital, Vita-Salute University, 20132 Milan, Italy
*
Author to whom correspondence should be addressed.
†
President of European Urogynaecological Association (EUGA).
Medicina 2023, 59(3), 580; https://doi.org/10.3390/medicina59030580
Submission received: 23 January 2023 / Revised: 3 March 2023 / Accepted: 13 March 2023 / Published: 15 March 2023
(This article belongs to the Section Obstetrics and Gynecology)
Versions Notes

Abstract

Background and Objectives: Stress urinary incontinence (SUI) negatively affects women’s quality of life, including sexual function. The aim of the current study was to evaluate the effect of polydimethylsiloxane (Macroplastique®) on sexual function in women of fertile age affected by SUI. Materials and Methods: Single-center prospective study. Sexually active women of fertile age with symptoms of pure SUI, which were urodynamically proven, were submitted to intraurethral Macroplastique® injection. At 6-months follow-up, their sexual function was evaluated with Female Sexual Function Index (FSFI), while the SUI cure rate was objectively assessed through a negative stress test and subjectively by a Patient Global Impression of Improvement (PGI-I) score < 3. The difference of coital incontinence prevalence was assessed between the baseline and the 6-month follow-up. Peri- and postoperative complications of Macroplastique® injection were recorded and classified according to the Clavien–Dindo system. Results: Twenty-one women fulfilled inclusion criteria and were submitted to Macroplastique® procedure. The concerning sexual function, desire, satisfaction, and overall FSFI score significantly improved. Since other domains were less impaired at the baseline, we could not assess significant improvement for all of them. We observed a complete regression of coital incontinence (0/21, 0%) in comparison with the baseline (5/21, 23.8%; p = 0.04). The objective SUI cure rate was 76% (16/21), while the subjective SUI cure rate was 80.9% (17/21). One woman developed de novo overactive bladder, and two women developed postoperative voiding dysfunction (self-solved in 24 h). Conclusions: The Macroplastique® urethral injection was demonstrated to be safe and effective in improving sexual function in sexually active women of fertile age affected by pure SUI, urodinamically proven at 6-months follow-up.
Keywords: urethral bulking agents; bulking agents; polydimethylsiloxane; Macroplastique; sexual function; stress urinary incontinence urethral bulking agents; bulking agents; polydimethylsiloxane; Macroplastique; sexual function; stress urinary incontinence

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MDPI and ACS Style

Serati, M.; Braga, A.; Scancarello, C.; De Rosa, A.; Frigerio, M.; Baruch, Y.; Torella, M.; Salvatore, S.; Ruffolo, A.F. Does the Polydimethylsiloxane Urethral Injection (Macroplastique®) Improve Sexual Function in Women, in Fertile Age, Affected by Stress Urinary Incontinence? Medicina 2023, 59, 580. https://doi.org/10.3390/medicina59030580

AMA Style

Serati M, Braga A, Scancarello C, De Rosa A, Frigerio M, Baruch Y, Torella M, Salvatore S, Ruffolo AF. Does the Polydimethylsiloxane Urethral Injection (Macroplastique®) Improve Sexual Function in Women, in Fertile Age, Affected by Stress Urinary Incontinence? Medicina. 2023; 59(3):580. https://doi.org/10.3390/medicina59030580

Chicago/Turabian Style

Serati, Maurizio, Andrea Braga, Chiara Scancarello, Andrea De Rosa, Matteo Frigerio, Yoav Baruch, Marco Torella, Stefano Salvatore, and Alessandro Ferdinando Ruffolo. 2023. "Does the Polydimethylsiloxane Urethral Injection (Macroplastique®) Improve Sexual Function in Women, in Fertile Age, Affected by Stress Urinary Incontinence?" Medicina 59, no. 3: 580. https://doi.org/10.3390/medicina59030580

APA Style

Serati, M., Braga, A., Scancarello, C., De Rosa, A., Frigerio, M., Baruch, Y., Torella, M., Salvatore, S., & Ruffolo, A. F. (2023). Does the Polydimethylsiloxane Urethral Injection (Macroplastique®) Improve Sexual Function in Women, in Fertile Age, Affected by Stress Urinary Incontinence? Medicina, 59(3), 580. https://doi.org/10.3390/medicina59030580

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