The Effect of Remimazolam Compared to Sevoflurane on Postoperative Shivering in Patients Undergoing Laparoscopic Gynecologic Surgery under General Anesthesia: A Prospective Randomized Controlled Trial
Abstract
:1. Introduction
2. Materials & Methods
2.1. Study Design and Setting
2.2. Anesthesia Protocol
2.3. Outcome Measurement
2.4. Statistical Analysis
3. Results
3.1. Study Population
3.2. Primary and Secondary Outcomes
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Group S (n = 34) | Group R (n = 36) | p-Value | SMD | |
---|---|---|---|---|
Age (yr) | 49.0 ± 8.1 | 49.7 ± 6.4 | 0.703 | −0.67 |
ASA (I/II) | 15/19 (44.1/55.9) | 20/16 (55.4/44.4) | 0.339 | |
Body mass index (kg/m2) | 24.0 ± 0.6 | 23.8 ± 0.9 | 0.705 | 0.14 |
Total fluid administered (mL) | 698.5 ± 108.4 | 730.6 ± 98.0 | 0.199 | −32.0 |
Duration of anesthesia (min) | 95.0 ± 8.3 | 96.9 ± 8.7 | 0.398 | −1.94 |
Type of surgery | 0.94 | |||
Laparoscopic subtotal hysterectomy | 12 (35.3) | 13 (36.1) | ||
Laparoscopic-assisted vaginal hysterectomy | 22 (64.7) | 23 (63.9) | ||
Duration of surgery (min) | 76.2 ± 9.2 | 76.9 ± 9.6 | 0.7485 | −0.77 |
Hypotension | 2 (5.9) | 0 (0) | 0.14 | |
Bradycardia | 0 (0) | 0 (0) |
Group S (n = 34) | Group R (n = 36) | p-Value | |
---|---|---|---|
Incidence of hypothermia (<36 °C) | 20 (58.8) | 10 (27.8) | 0.009 |
Incidence of PS | 14 (41.2) | 7 (19.4) | 0.047 |
Severity of PS | 0.034 | ||
Grade 0 | 20 (20.8) | 29 (46.7) | |
Grade 1 | 3 (41.7) | 5 (40.0) | |
Grade 2 | 8 (33.3) | 2 (13.3) | |
Grade 3 | 3 (8.8) | 0 (0) | |
Meperidine administered for the treatment of PS | 11 (32.4) | 2 (5.6) | 0.004 |
No Hypothermia | Hypothermia | Cramer’s V (φc) Coefficient | p-Value | ||
---|---|---|---|---|---|
Group S | PS | 0.414 | 0.121 | ||
Grade 0 | 11 (78.6) | 9 (45.0) | |||
Grade 1 | 0 (0.0) | 3 (15.0) | |||
Grade 2 | 3 (21.4) | 5 (25.0) | |||
Grade 3 | 0 (0.0) | 3 (15.0) | |||
Group R | PS | 0.418 | 0.043 | ||
Grade 0 | 23 (88.5) | 6 (60.0) | |||
Grade 1 | 3 (11.5) | 2 (20.0) | |||
Grade 2 | 0 (0) | 2 (20.0) | |||
Total | PS | 0.401 | 0.010 | ||
Grade 0 | 34 (85.0) | 15 (50.0) | |||
Grade 1 | 3 (7.5) | 5 (16.7) | |||
Grade 2 | 3 (7.5) | 7 (23.3) | |||
Grade 3 | 0 (0) | 3 (10.0) |
No Hypothermia | Hypothermia | Cramer’s V (φc) Coefficient | p-Value | ||
---|---|---|---|---|---|
Group S | PS | 0.195 | 0.255 | ||
≤Grade 1 | 11 (78.6) | 12 (60.0) | |||
≥Grade 2 | 3 (21.4) | 8 (40.0) | |||
Group R | PS | 0.391 | 0.019 | ||
≤Grade 1 | 26 (100) | 8 (80.0) | |||
≥Grade 2 | 0 | 2 (20.0) | |||
Total | PS | 0.329 | 0.006 | ||
≤Grade 1 | 37 | 20 (66.7) | |||
≥Grade 2 | 3 | 10 (33.3) |
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Lee, C.; Lee, C.; Lee, H.; Park, J.; Lim, J.; Kim, H. The Effect of Remimazolam Compared to Sevoflurane on Postoperative Shivering in Patients Undergoing Laparoscopic Gynecologic Surgery under General Anesthesia: A Prospective Randomized Controlled Trial. Medicina 2023, 59, 578. https://doi.org/10.3390/medicina59030578
Lee C, Lee C, Lee H, Park J, Lim J, Kim H. The Effect of Remimazolam Compared to Sevoflurane on Postoperative Shivering in Patients Undergoing Laparoscopic Gynecologic Surgery under General Anesthesia: A Prospective Randomized Controlled Trial. Medicina. 2023; 59(3):578. https://doi.org/10.3390/medicina59030578
Chicago/Turabian StyleLee, Cheol, Cheolhyeong Lee, Hayoung Lee, Jeongki Park, Junsung Lim, and Hyungtae Kim. 2023. "The Effect of Remimazolam Compared to Sevoflurane on Postoperative Shivering in Patients Undergoing Laparoscopic Gynecologic Surgery under General Anesthesia: A Prospective Randomized Controlled Trial" Medicina 59, no. 3: 578. https://doi.org/10.3390/medicina59030578