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Volume 59
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Article

Effect of Percutaneous Biliary Drainage on Enzyme Activity of Serum Matrix Metalloproteinase-9 in Patients with Malignant Hilar Obstructive Hyperbilirubinemia

by
Aleksandar Filipović
1,2,
Dragan Mašulović
1,2,
Kristina Gopčević
1,3,
Danijel Galun
1,4,
Aleksa Igić
2,
Dušan Bulatović
2,
Miloš Zakošek
2 and
Tamara Filipović
1,5,*
1
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
2
Center for Radiology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia
3
Institute for Chemistry in Medicine, 11000 Belgrade, Serbia
4
HPB Unit, Clinic for Digestive Surgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia
5
Institute for Rehabilitation, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Medicina 2023, 59(2), 336; https://doi.org/10.3390/medicina59020336
Submission received: 27 November 2022 / Revised: 29 January 2023 / Accepted: 5 February 2023 / Published: 10 February 2023
(This article belongs to the Special Issue Updates in Liver Malignancies)
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Abstract

Background and Objectives. Cholestasis activates complex mechanisms of liver injury and as a result has an increased production of matrix metalloproteinases (MMP). Depending on the stage of liver disease, different matrix metalloproteinases expressions have been detected and could serve as indirect biomarkers as well as therapeutic targets. MMP-9 proteolytic activity has a proven role in both liver regeneration and neoplastic cell invasion in various malignancies. The purpose of this prospective cohort study was to evaluate the effect of external biliary drainage on enzyme activity of MMP-9 in the serum of patients with malignant hilar biliary obstruction. Materials and Methods. Between November 2020 and April 2021, 45 patients with malignant hilar biliary obstruction underwent percutaneous biliary drainage following determination of serum MMP-9 enzyme activity (before treatment and 4 weeks after the treatment) by gelatin zymography. Results. MMP-9 values decreased statistically significantly 4 weeks after percutaneous biliary drainage (p = 0.028) as well as the value of total bilirubin (p < 0.001), values of direct bilirubin (p < 0.001), aspartate aminotransferase (AST) (p < 0.001), alanine transaminase (ALT) (p < 0.001), and gamma-glutamyl transferase (GGT) (p < 0.001). Conclusions. In patients with malignant hilar biliary obstruction treated by external percutaneous biliary drainage for cholestasis resolution, a significant reduction in MMP-9 serum values was noted 4 weeks after the treatment.
Keywords: biliary drainage; matrix metalloproteinase; malignant hilar obstruction biliary drainage; matrix metalloproteinase; malignant hilar obstruction

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MDPI and ACS Style

Filipović, A.; Mašulović, D.; Gopčević, K.; Galun, D.; Igić, A.; Bulatović, D.; Zakošek, M.; Filipović, T. Effect of Percutaneous Biliary Drainage on Enzyme Activity of Serum Matrix Metalloproteinase-9 in Patients with Malignant Hilar Obstructive Hyperbilirubinemia. Medicina 2023, 59, 336. https://doi.org/10.3390/medicina59020336

AMA Style

Filipović A, Mašulović D, Gopčević K, Galun D, Igić A, Bulatović D, Zakošek M, Filipović T. Effect of Percutaneous Biliary Drainage on Enzyme Activity of Serum Matrix Metalloproteinase-9 in Patients with Malignant Hilar Obstructive Hyperbilirubinemia. Medicina. 2023; 59(2):336. https://doi.org/10.3390/medicina59020336

Chicago/Turabian Style

Filipović, Aleksandar, Dragan Mašulović, Kristina Gopčević, Danijel Galun, Aleksa Igić, Dušan Bulatović, Miloš Zakošek, and Tamara Filipović. 2023. "Effect of Percutaneous Biliary Drainage on Enzyme Activity of Serum Matrix Metalloproteinase-9 in Patients with Malignant Hilar Obstructive Hyperbilirubinemia" Medicina 59, no. 2: 336. https://doi.org/10.3390/medicina59020336

APA Style

Filipović, A., Mašulović, D., Gopčević, K., Galun, D., Igić, A., Bulatović, D., Zakošek, M., & Filipović, T. (2023). Effect of Percutaneous Biliary Drainage on Enzyme Activity of Serum Matrix Metalloproteinase-9 in Patients with Malignant Hilar Obstructive Hyperbilirubinemia. Medicina, 59(2), 336. https://doi.org/10.3390/medicina59020336

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