Impact of Depression on Cognitive Function and Disease Severity in Idiopathic Cervical Dystonia Patients: One-Center Data in Cross-Sectional Study
Abstract
:1. Introduction
2. Materials and Methods
- Patients had reached 18 years of age or older with a diagnosis of idiopathic focal or segmental dystonia with adult-onset affecting cervical muscles (patients who experienced either long-lasting involuntary contractions or periodic, intermittent spasms of the neck muscles that cause the neck to turn in different ways);
- Symptoms were experienced for at least one year (not newly diagnosed CD);
- Patients had agreed to take part in the study.
- Secondary or pseudodystonia of the neck muscles;
- Patients with low cognitive skills who were not able to fill in the questionnaire, due to other possible comorbidities (dementia, alcohol use disorder, posttraumatic brain injury, metabolic disorders, Parkinson’s disease, Huntington’s disease or patients after stroke).
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Dystonia Severity and Cognitive Assessment in Cervical Dystonia (CD) Patients Depending on Depressive Signs | ||||||
---|---|---|---|---|---|---|
Nonsignificant Depression | Significant Depression | Test | U Value | Z Test | p Value | |
Number of Patients, N (%) | 34 (65.4%) | 18 (34.6%) | - | - | - | - |
Severity of dystonia | ||||||
TSUI scale score | 7.5 (6.0; 9.0) | 8.0 (6.8; 8.0) | Mann–Whitney U Test | 261.500 | −0.864 | 0.387 |
TWSTRS scale score-physical finding part | 12.0 (10.0; 14.3) | 13.0 (10.0; 15.0) | Mann–Whitney U Test | 246.000 | −1.164 | 0.244 |
Self-assessment of the disease | ||||||
Mild dystonia | 8 (23.5%) | 0 (0%) | Fisher’s Exact Test | - | - | 0.004 |
Moderately-severe dystonia | 25 (73.5%) | 13 (72.2%) | ||||
Severe dystonia | 1 (3.0%) | 5 (27.8%) | ||||
MoCA scale score, median (Q25; Q75) | 26.0 (23.8; 28.0) | 25.0 (23.0; 26.3) | Mann–Whitney U Test | 224.500 | −1.578 | 0.115 |
Special MoCA scale profiles, median (Q25; Q75) | ||||||
Visuospatial/Executive abilities | 4.0 (3.0; 5.0) | 4.0 (3.0; 5.0) | Mann–Whitney U Test | 267.000 | −0.791 | 0.429 |
Attention/concentration | 6.0 (5.8; 6.0) | 6.0 (5.0; 6.0) | 242.000 | −1.528 | 0.126 | |
Language | 2.5 (2.0; 3.0) | 2.0 (1.8; 3.0) | 258.000 | −1.005 | 0.315 | |
Abstraction | 2.0 (1.0; 2.0) | 1.0 (1.0; 2.0) | 221.000 | −1.911 | 0.056 | |
Short-term memory | 3.0 (2.0; 4.0) | 3.0 (2.8; 4.0) | 297.000 | −0.178 | 0.859 |
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Meļņikova, V.; Valante, R.; Valtiņa-Briģe, S.; Logina, I. Impact of Depression on Cognitive Function and Disease Severity in Idiopathic Cervical Dystonia Patients: One-Center Data in Cross-Sectional Study. Medicina 2022, 58, 1793. https://doi.org/10.3390/medicina58121793
Meļņikova V, Valante R, Valtiņa-Briģe S, Logina I. Impact of Depression on Cognitive Function and Disease Severity in Idiopathic Cervical Dystonia Patients: One-Center Data in Cross-Sectional Study. Medicina. 2022; 58(12):1793. https://doi.org/10.3390/medicina58121793
Chicago/Turabian StyleMeļņikova, Vlada, Ramona Valante, Solveiga Valtiņa-Briģe, and Ināra Logina. 2022. "Impact of Depression on Cognitive Function and Disease Severity in Idiopathic Cervical Dystonia Patients: One-Center Data in Cross-Sectional Study" Medicina 58, no. 12: 1793. https://doi.org/10.3390/medicina58121793