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Presepsin as Early Marker of Sepsis in Emergency Department: A Narrative Review

Emergency Medicine Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Author to whom correspondence should be addressed.
Academic Editors: Antonio Mirijello and Alberto Tosoni
Medicina 2021, 57(8), 770;
Received: 30 June 2021 / Revised: 21 July 2021 / Accepted: 24 July 2021 / Published: 29 July 2021
(This article belongs to the Special Issue New Strategies for Treatment of Sepsis)
The diagnosis and treatment of sepsis have always been a challenge for the physician, especially in critical care setting such as emergency department (ED), and currently sepsis remains one of the major causes of mortality. Although the traditional definition of sepsis based on systemic inflammatory response syndrome (SIRS) criteria changed in 2016, replaced by the new criteria of SEPSIS-3 based on organ failure evaluation, early identification and consequent early appropriated therapy remain the primary goal of sepsis treatment. Unfortunately, currently there is a lack of a foolproof system for making early sepsis diagnosis because conventional diagnostic tools like cultures take a long time and are often burdened with false negatives, while molecular techniques require specific equipment and have high costs. In this context, biomarkers, such as C-Reactive Protein (CRP) and Procalcitonin (PCT), are very useful tools to distinguish between normal and pathological conditions, graduate the disease severity, guide treatment, monitor therapeutic responses and predict prognosis. Among the new emerging biomarkers of sepsis, Presepsin (P-SEP) appears to be the most promising. Several studies have shown that P-SEP plasma levels increase during bacterial sepsis and decline in response to appropriate therapy, with sensitivity and specificity values comparable to those of PCT. In neonatal sepsis, P-SEP compared to PCT has been shown to be more effective in diagnosing and guiding therapy. Since in sepsis the P-SEP plasma levels increase before those of PCT and since the current methods available allow measurement of P-SEP plasma levels within 17 min, P-SEP appears a sepsis biomarker particularly suited to the emergency department and critical care. View Full-Text
Keywords: Presepsin; sepsis; emergency department; critical care; ICU Presepsin; sepsis; emergency department; critical care; ICU
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MDPI and ACS Style

Piccioni, A.; Santoro, M.C.; de Cunzo, T.; Tullo, G.; Cicchinelli, S.; Saviano, A.; Valletta, F.; Pascale, M.M.; Candelli, M.; Covino, M.; Franceschi, F. Presepsin as Early Marker of Sepsis in Emergency Department: A Narrative Review. Medicina 2021, 57, 770.

AMA Style

Piccioni A, Santoro MC, de Cunzo T, Tullo G, Cicchinelli S, Saviano A, Valletta F, Pascale MM, Candelli M, Covino M, Franceschi F. Presepsin as Early Marker of Sepsis in Emergency Department: A Narrative Review. Medicina. 2021; 57(8):770.

Chicago/Turabian Style

Piccioni, Andrea, Michele C. Santoro, Tommaso de Cunzo, Gianluca Tullo, Sara Cicchinelli, Angela Saviano, Federico Valletta, Marco M. Pascale, Marcello Candelli, Marcello Covino, and Francesco Franceschi. 2021. "Presepsin as Early Marker of Sepsis in Emergency Department: A Narrative Review" Medicina 57, no. 8: 770.

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