Next Article in Journal
The Management of Prodromal Symptoms of Bipolar Disorder: Available Options and Future Perspectives
Previous Article in Journal
The Application of Control Materials for Ongoing Quality Management of Next-Generation Sequencing in a Clinical Genetic Laboratory
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Medicina
Volume 57
Issue 6
10.3390/medicina57060544
Review Report
medicina-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Case Report
Peer-Review Record

Rare Intercondylar Distal Femoral Brodie’s Abscess in a 21-Year-Old Man Who Refused Medical Care for Three Years after Initial Symptoms

Medicina 2021, 57(6), 544; https://doi.org/10.3390/medicina57060544
by Bogdan Gheorghe Hogea 1,2,3, Jenel Marian Patrascu, Jr. 1,2,3, Adrian Emil Lazarescu 1,2,3,*, Louchi El Mehdi 2, Andrei Daniel Bolovan 2, Lavinia Maria Hogea 1, Adrian Cosmin Ilie 1, Bogdan Corneliu Andor 1,2,3 and Jenel Marian Patrascu 1,2,3
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Medicina 2021, 57(6), 544; https://doi.org/10.3390/medicina57060544
Submission received: 14 April 2021 / Revised: 15 May 2021 / Accepted: 25 May 2021 / Published: 28 May 2021

Round 1

Reviewer 1 Report

The article is great and very interesting. The topic is well explained, I suggest you to amplify the references, for example by explaining the specificity of RMN for abscess as point out in this article "A rare case of Spinal Epidural Abscess following mesotherapy: a challenging diagnosis and the importance of clinical risk management." , or talking about new markers that could lead to an early diagnosis of a chronic septic state (es: " An immunohistochemical study of the diagnostic value of TREM-1 as marker for fatal sepsis cases"). 

Good luck!

 

Author Response

Thankyou very much for your time and the clear observations,

I have added a few more refferences in order to better explain the role of each imaging investigation in osteomyelitis in general, and have added these explanations in the material and methods and the discussions segments of our manuscript.

With utmost respect

Best regards

Adrian Emil Lazarescu

Reviewer 2 Report

REVIEW COMMENT:

2. Materials and Methods

It would be interesting to know if the patient remembers previous trauma in that area. In fact a hypothesis about the formation of Brodie’s abscess suggests that the predisposition of bone to infection increases after minor traumas (without open wounds) [Van der Naald N, Smeeing DPJ, Houwert RM, Hietbrink F, Govaert GAM, van der Velde D. Brodie’s abscess: A systematic review of reported cases. J Bone Jt Infect. 2019;4:33–9]

3. Management and outcome

it would be recommended to specify whether antibiotic-loaded cement was used.

Author Response

Thankyou sincerely for your time and clear observations

I have added in the anamnestic exam that the patient does not remember any traumatic history and the paper you suggested was first reference in our list.

Also i explained better that we used antibiotics locally (vancomicin) as the last step of the debridement just before cementing. We felt that we should follow the preparation indications exactly and we thought that mixing antibiotics might alter the properties of the bone inducing cement.

Again thankyou for reviewing our paper

With utmost respect

Dr. Lazarescu Adrian Emil

Back to TopTop