Unique Associations between Insulin-Like Growth Factor Binding Protein-1, Insulin-Like Growth Factor-1 and T Cell Immunoglobulin Mucin 3 in Successful Twin Pregnancies Conceived with Donor Oocytes
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Assays
2.3. Data Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Characteristic | Natural Conception | Assisted Reproduction | IVF-Donor Oocytes |
---|---|---|---|
n = 43 | n = 44 | n = 25 | |
Age in years | 34 (31–36) | 35 (33–38.7) | 42 (37–45) b |
BMI (kg/m2) | 21.1 (19.9–23.9) | 21.4 (20.2–23.1) | 23.3 (19.9–28.2) |
Parity >0 | 51.2% | 6.8% | 4% b |
Betamethasone | 32.5% | 31.8% | 16% |
Gestational Diabetes | 18.6% | 11.3% | 28% |
Cesarean section | 97% | 90% | 95% |
Gestational age sample a | 24 (19–28) | 19 (16–26) | 21 (19–26) |
Gestational age delivery a | 37 (34–37) | 37 (35.5–38) | 36 (35–37) |
Birthweight 1st baby | 2430 (1930–2550) | 2530 (2190–29,000) | 2390 (1950–2662) |
Birthweight 2nd baby | 2290 (2140–2650) | 2420 (2090–2710) | 2230 (1867–2655) |
Smoking | 9.3% | 0 | 4% |
White race | 93% | 95.5% | 96% |
Group | Median (Range) | ||
---|---|---|---|
IGFBP-1 a | IGF-1 a | Tim-3 b | |
Spontaneous conception | 51.2 (41.1–61.4) | 2.4 (1.1–3.9) | 201 (132–288) |
Assisted reproduction | 52.4 (39.3–61.7) | 2.5 (1.4–4.5) | 215 (159–263) |
Donor oocytes | 41.4 (24.2–48.6) c | 2.7 (1.5–4.3) | 197 (155–287) |
Pair | Group | Spearman r | p Value |
---|---|---|---|
IGFBP-IGF-1 | Spontaneous | NS | NS |
Assisted reproduction | NS | NS | |
Donor oocytes | −0.431 | 0.032 | |
IGFBP-1-Tim-3 | Spontaneous | NS | NS |
Assisted reproduction a | −0.552 | 0.018 | |
Donor oocytes | −0.495 | 0.012 | |
IGF-1-Tim-3 | Spontaneous | NS | NS |
Assisted reproduction | NS | NS | |
Donor oocytes | NS | NS |
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Sisti, G.; Di Tommaso, M.; Paccosi, S.; Parenti, A.; Seravalli, V.; Cuzzola, R.; Witkin, S.S. Unique Associations between Insulin-Like Growth Factor Binding Protein-1, Insulin-Like Growth Factor-1 and T Cell Immunoglobulin Mucin 3 in Successful Twin Pregnancies Conceived with Donor Oocytes. Medicina 2019, 55, 144. https://doi.org/10.3390/medicina55050144
Sisti G, Di Tommaso M, Paccosi S, Parenti A, Seravalli V, Cuzzola R, Witkin SS. Unique Associations between Insulin-Like Growth Factor Binding Protein-1, Insulin-Like Growth Factor-1 and T Cell Immunoglobulin Mucin 3 in Successful Twin Pregnancies Conceived with Donor Oocytes. Medicina. 2019; 55(5):144. https://doi.org/10.3390/medicina55050144
Chicago/Turabian StyleSisti, Giovanni, Mariarosaria Di Tommaso, Sara Paccosi, Astrid Parenti, Viola Seravalli, Roberta Cuzzola, and Steven S. Witkin. 2019. "Unique Associations between Insulin-Like Growth Factor Binding Protein-1, Insulin-Like Growth Factor-1 and T Cell Immunoglobulin Mucin 3 in Successful Twin Pregnancies Conceived with Donor Oocytes" Medicina 55, no. 5: 144. https://doi.org/10.3390/medicina55050144
APA StyleSisti, G., Di Tommaso, M., Paccosi, S., Parenti, A., Seravalli, V., Cuzzola, R., & Witkin, S. S. (2019). Unique Associations between Insulin-Like Growth Factor Binding Protein-1, Insulin-Like Growth Factor-1 and T Cell Immunoglobulin Mucin 3 in Successful Twin Pregnancies Conceived with Donor Oocytes. Medicina, 55(5), 144. https://doi.org/10.3390/medicina55050144