Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation

Marina Aunapuu; Andres Arend; Mai Ots; Mara Pilmane

doi:10.3390/medicina46030029

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Article

10 March 2010

Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation

and

Department of Anatomy, University of Tartu, Estonia

Department of Morphology, Estonian University of Life Sciences, Tartu

Department of Internal Medicine, University of Tartu, Estonia

⁴

Institute of Anthropology and Anatomy, Riga Stradins University, Latvia

Medicina2010, 46(3), 204;https://doi.org/10.3390/medicina46030029

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Abstract

Cell proliferation and apoptosis in the remnant rat kidney after treatment with lowdose irradiation was investigated.
Material and methods. In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9).
Results. Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation.
Conclusion. The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury.

Keywords:

remnant kidney; rat; low-dose radiation; cell proliferation; apoptosis

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