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Volume 47
Issue 11
10.3390/cimb47110966
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Review

Molecular Mechanisms of Cold Stress Response in Strawberry and Breeding Strategies

by
Xiang Zhang
,
Jiajie Yu
,
Shuang Wang
,
Rongjia Qiao
,
Jianjun Shen
,
Weixiao Li
,
Fei Zhou
and
Xiaohong Li
*
School of Agriculture, Liaodong University, Dandong 118003, China
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2025, 47(11), 966; https://doi.org/10.3390/cimb47110966
Submission received: 28 September 2025 / Revised: 6 November 2025 / Accepted: 18 November 2025 / Published: 20 November 2025
(This article belongs to the Section Molecular Plant Sciences)
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Abstract

As a globally popular crop, strawberry is highly susceptible to cold stress, which significantly limits its cultivation and yield. This review synthesizes current knowledge on the morphological, physiological, and molecular responses of strawberry plants to cold stress. Morphologically, cold stress induces chlorosis, necrosis, and growth retardation, while physiologically, it impairs photosynthesis and membrane integrity and triggers oxidative stress. At the molecular level, the cold acclimation process in plants is orchestrated by a sophisticated regulatory network centered on the ICE-CBF/DREB signaling pathway and incorporating transcription factors, epigenetic modifications, and non-coding RNAs. The accumulation of protective compounds like proline, anthocyanins, and antioxidants is a key metabolic adaptation. Finally, we discuss integrative management practices and future breeding strategies, including genetic engineering, marker-assisted selection, and the use of plant growth-promoting rhizobacteria to enhance cold tolerance. This comprehensive overview provides valuable insights for developing resilient strawberry varieties in the face of unpredictable climate events.
Keywords: cold stress; strawberry; molecular pathway; reactive oxygen species (ROS); antioxidants; cold acclimation; transcription factors; cold-tolerant breeding cold stress; strawberry; molecular pathway; reactive oxygen species (ROS); antioxidants; cold acclimation; transcription factors; cold-tolerant breeding
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MDPI and ACS Style

Zhang, X.; Yu, J.; Wang, S.; Qiao, R.; Shen, J.; Li, W.; Zhou, F.; Li, X. Molecular Mechanisms of Cold Stress Response in Strawberry and Breeding Strategies. Curr. Issues Mol. Biol. 2025, 47, 966. https://doi.org/10.3390/cimb47110966

AMA Style

Zhang X, Yu J, Wang S, Qiao R, Shen J, Li W, Zhou F, Li X. Molecular Mechanisms of Cold Stress Response in Strawberry and Breeding Strategies. Current Issues in Molecular Biology. 2025; 47(11):966. https://doi.org/10.3390/cimb47110966

Chicago/Turabian Style

Zhang, Xiang, Jiajie Yu, Shuang Wang, Rongjia Qiao, Jianjun Shen, Weixiao Li, Fei Zhou, and Xiaohong Li. 2025. "Molecular Mechanisms of Cold Stress Response in Strawberry and Breeding Strategies" Current Issues in Molecular Biology 47, no. 11: 966. https://doi.org/10.3390/cimb47110966

APA Style

Zhang, X., Yu, J., Wang, S., Qiao, R., Shen, J., Li, W., Zhou, F., & Li, X. (2025). Molecular Mechanisms of Cold Stress Response in Strawberry and Breeding Strategies. Current Issues in Molecular Biology, 47(11), 966. https://doi.org/10.3390/cimb47110966

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