Next Article in Journal
Integrated MicroRNA-mRNA Analyses of the Osteogenic Differentiation of Human Dental Pulp Stem Cells by a Helioxanthin Derivative
Next Article in Special Issue
Identifying Herbal Candidates and Active Compounds for Psoriasis Through Multiscale Network Analysis
Previous Article in Journal
Improving Lipid Content in the Diatom Phaeodactylum tricornutum by the Knockdown of the Enoyl-CoA Hydratase Using CRISPR Interference
Previous Article in Special Issue
Investigating the Phytochemical Composition, Antioxidant, and Anti-Inflammatory Potentials of Cassinopsis ilicifolia (Hochst.) Kuntze Extract against Some Oxidative Stress and Inflammation Molecular Markers
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
CIMB
Volume 46
Issue 10
10.3390/cimb46100650
cimb-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats

by
Svetlana S. Kirikovich
1,*,†,
Evgeniy V. Levites
1,†,
Anastasia S. Proskurina
1,
Genrikh S. Ritter
1,
Evgeniya V. Dolgova
1,
Vera S. Ruzanova
1,
Sofya G. Oshihmina
1,
Julia S. Snegireva
2,
Svetlana G. Gamaley
3,
Galina M. Sysoeva
3,
Elena D. Danilenko
3,
Oleg S. Taranov
3,
Alexandr A. Ostanin
4,
Elena R. Chernykh
4,
Nikolay A. Kolchanov
1 and
Sergey S. Bogachev
1,*
1
Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
2
Faculty of Biotechnologies, ITMO University, 191002 Saint Petersburg, Russia
3
State Research Center of Virology and Biotechnology “Vector”, 630559 Koltsovo, Russia
4
Research Institute of Fundamental and Clinical Immunology, 630099 Novosibirsk, Russia
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2024, 46(10), 10934-10959; https://doi.org/10.3390/cimb46100650
Submission received: 28 August 2024 / Revised: 21 September 2024 / Accepted: 25 September 2024 / Published: 28 September 2024
(This article belongs to the Special Issue Role of Natural Products in Inflammatory Diseases)
Browse Figures
Versions Notes

Abstract

Vitamin D3 transporter (DBP) is a multifunctional protein. Site-specific deglycosylation results in its conversion to group-specific component protein-derived macrophage activating factor (GcMAF), which is capable of activating macrophages. It has been shown that depending on precursor conversion conditions, the resulting GcMAF activates mouse peritoneal macrophages towards synthesis of either pro- (IL-1β, TNF-α—M1 phenotype) or anti-inflammatory (TGF-β, IL-10—M2 phenotype) cytokines. The condition for the transition of the direction of the inflammatory response of macrophages when exposed to GcMAF is the initial glycosylated state of the population of DBP molecules and the associated effective deglycosylation of DBP by β-galactosidase. In vivo experiments with GcMAF exhibiting anti-inflammatory properties on models of induced arthritis in mice and cystitis in rats indicate a significant anti-inflammatory effect of the macrophage activator. The feasibility of unidirectional induction of anti-inflammatory properties of macrophages allows creation of combined therapeutic platforms where M2 macrophages are among the key therapeutic components.
Keywords: DBP; sialic acid/galactose residue deglycosylation; GcMAF; CLEC10A; M1/M2 macrophages; IL-1β; TNF-α; TGF-β; IL-10; induced cystitis; induced arthritis DBP; sialic acid/galactose residue deglycosylation; GcMAF; CLEC10A; M1/M2 macrophages; IL-1β; TNF-α; TGF-β; IL-10; induced cystitis; induced arthritis

Share and Cite

MDPI and ACS Style

Kirikovich, S.S.; Levites, E.V.; Proskurina, A.S.; Ritter, G.S.; Dolgova, E.V.; Ruzanova, V.S.; Oshihmina, S.G.; Snegireva, J.S.; Gamaley, S.G.; Sysoeva, G.M.; et al. Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats. Curr. Issues Mol. Biol. 2024, 46, 10934-10959. https://doi.org/10.3390/cimb46100650

AMA Style

Kirikovich SS, Levites EV, Proskurina AS, Ritter GS, Dolgova EV, Ruzanova VS, Oshihmina SG, Snegireva JS, Gamaley SG, Sysoeva GM, et al. Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats. Current Issues in Molecular Biology. 2024; 46(10):10934-10959. https://doi.org/10.3390/cimb46100650

Chicago/Turabian Style

Kirikovich, Svetlana S., Evgeniy V. Levites, Anastasia S. Proskurina, Genrikh S. Ritter, Evgeniya V. Dolgova, Vera S. Ruzanova, Sofya G. Oshihmina, Julia S. Snegireva, Svetlana G. Gamaley, Galina M. Sysoeva, and et al. 2024. "Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats" Current Issues in Molecular Biology 46, no. 10: 10934-10959. https://doi.org/10.3390/cimb46100650

APA Style

Kirikovich, S. S., Levites, E. V., Proskurina, A. S., Ritter, G. S., Dolgova, E. V., Ruzanova, V. S., Oshihmina, S. G., Snegireva, J. S., Gamaley, S. G., Sysoeva, G. M., Danilenko, E. D., Taranov, O. S., Ostanin, A. A., Chernykh, E. R., Kolchanov, N. A., & Bogachev, S. S. (2024). Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats. Current Issues in Molecular Biology, 46(10), 10934-10959. https://doi.org/10.3390/cimb46100650

Article Metrics

Back to TopTop