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Article

Association of Single Nucleotide Polymorphisms from Angiogenesis-Related Genes, ANGPT2, TLR2 and TLR9, with Spontaneous Preterm Labor

by
Wioletta Izabela Wujcicka
1,*,
Marian Kacerovsky
2,3,
Adrian Krygier
4,
Michał Krekora
5,6,
Piotr Kaczmarek
7 and
Mariusz Grzesiak
6,8
1
Scientific Laboratory of the Center of Medical Laboratory Diagnostics and Screening, Polish Mother’s Memorial Hospital-Research Institute, 93-338 Lodz, Poland
2
Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Charles University, 500 03 Hradec Kralove, Czech Republic
3
Biomedical Research Center, University Hospital Hradec Kralove, 500 03 Hradec Kralove, Czech Republic
4
Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz, 90-151 Lodz, Poland
5
Department of Obstetrics and Gynecology, Polish Mother’s Memorial Hospital-Research Institute, 93-338 Lodz, Poland
6
Department of Gynecology and Obstetrics, Medical University of Lodz, 93-338 Lodz, Poland
7
Department of Gynecology, Reproduction and Fetal Therapy, and Diagnostics and Treatment of Infertility, Polish Mother’s Memorial Hospital-Research Institute, 93-338 Lodz, Poland
8
Department of Perinatology, Obstetrics and Gynecology, Polish Mother’s Memorial Hospital-Research Institute, 93-338 Lodz, Poland
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2022, 44(7), 2939-2955; https://doi.org/10.3390/cimb44070203
Submission received: 17 May 2022 / Revised: 25 June 2022 / Accepted: 27 June 2022 / Published: 30 June 2022
(This article belongs to the Topic Blood Physiology: Molecular Mechanisms of Vascular Wall Functioning)
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Abstract

In this study, we hypothesized that the changes localized at angiopoietin-2 (ANGPT2), granulocyte-macrophage colony-stimulating factor (CSF2), fms-related tyrosine kinase 1 (FLT1) and toll-like receptor (TLR) 2, TLR6 and TLR9 genes were associated with spontaneous preterm labor (PTL), as well as with possible genetic alterations on PTL-related coagulation. This case-control genetic association study aimed to identify single nucleotide polymorphisms (SNPs) for the aforementioned genes, which are correlated with genetic risk or protection against PTL in Polish women. The study was conducted in 320 patients treated between 2016 and 2020, including 160 women with PTL and 160 term controls in labor. We found that ANGPT2 rs3020221 AA homozygotes were significantly less common in PTL cases than in controls, especially after adjusting for activated partial thromboplastin time (APTT) and platelet (PLT) parameters. TC heterozygotes for TLR2 rs3804099 were associated with PTL after correcting for anemia, vaginal bleeding, and history of threatened miscarriage or PTL. TC and CC genotypes in TLR9 rs187084 were significantly less common in women with PTL, compared to the controls, after adjusting for bleeding and gestational diabetes. For the first time, it was shown that three polymorphisms—ANGPT2 rs3020221, TLR2 rs3804099 and TLR9 rs187084 —were significantly associated with PTL, adjusted by pregnancy development influencing factors.
Keywords: spontaneous preterm labor; pregnancy; angiogenesis; genotyping; single nucleotide polymorphism; restriction fragment length polymorphism spontaneous preterm labor; pregnancy; angiogenesis; genotyping; single nucleotide polymorphism; restriction fragment length polymorphism

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MDPI and ACS Style

Wujcicka, W.I.; Kacerovsky, M.; Krygier, A.; Krekora, M.; Kaczmarek, P.; Grzesiak, M. Association of Single Nucleotide Polymorphisms from Angiogenesis-Related Genes, ANGPT2, TLR2 and TLR9, with Spontaneous Preterm Labor. Curr. Issues Mol. Biol. 2022, 44, 2939-2955. https://doi.org/10.3390/cimb44070203

AMA Style

Wujcicka WI, Kacerovsky M, Krygier A, Krekora M, Kaczmarek P, Grzesiak M. Association of Single Nucleotide Polymorphisms from Angiogenesis-Related Genes, ANGPT2, TLR2 and TLR9, with Spontaneous Preterm Labor. Current Issues in Molecular Biology. 2022; 44(7):2939-2955. https://doi.org/10.3390/cimb44070203

Chicago/Turabian Style

Wujcicka, Wioletta Izabela, Marian Kacerovsky, Adrian Krygier, Michał Krekora, Piotr Kaczmarek, and Mariusz Grzesiak. 2022. "Association of Single Nucleotide Polymorphisms from Angiogenesis-Related Genes, ANGPT2, TLR2 and TLR9, with Spontaneous Preterm Labor" Current Issues in Molecular Biology 44, no. 7: 2939-2955. https://doi.org/10.3390/cimb44070203

APA Style

Wujcicka, W. I., Kacerovsky, M., Krygier, A., Krekora, M., Kaczmarek, P., & Grzesiak, M. (2022). Association of Single Nucleotide Polymorphisms from Angiogenesis-Related Genes, ANGPT2, TLR2 and TLR9, with Spontaneous Preterm Labor. Current Issues in Molecular Biology, 44(7), 2939-2955. https://doi.org/10.3390/cimb44070203

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