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Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets

Center of Biomedical Research La Sabana University-CIBUS, School of Medicine, Universidad de La Sabana, Campus Del Puente del Común, km 7 Autopista Norte de Bogota, Chía 250001, Colombia
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Pharmaceuticals 2012, 5(9), 963-990; https://doi.org/10.3390/ph5090963
Received: 26 June 2012 / Revised: 21 July 2012 / Accepted: 17 August 2012 / Published: 12 September 2012
(This article belongs to the Special Issue Epigenetic Therapies and Biomarkers)
The development of cancer involves an immense number of factors at the molecular level. These factors are associated principally with alterations in the epigenetic mechanisms that regulate gene expression profiles. Studying the effects of chromatin structure alterations, which are caused by the addition/removal of functional groups to specific histone residues, are of great interest as a promising way to identify markers for cancer diagnosis, classify the disease and determine its prognosis, and these markers could be potential targets for the treatment of this disease in its different forms. This manuscript presents the current point of view regarding members of the recently described family of proteins that exhibit histone demethylase activity; histone demethylases are genetic regulators that play a fundamental role in both the activation and repression of genes and whose expression has been observed to increase in many types of cancer. Some fundamental aspects of their association with the development of cancer and their relevance as potential targets for the development of new therapeutic strategies at the epigenetic level are discussed in the following manuscript. View Full-Text
Keywords: neoplasia; epigenomics; histone demethylases; histone demethylases with a jumonji domain neoplasia; epigenomics; histone demethylases; histone demethylases with a jumonji domain
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Lizcano, F.; Garcia, J. Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets. Pharmaceuticals 2012, 5, 963-990.

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