Next Article in Journal
Heat Shock Protein 90 (Hsp90) Expression and Breast Cancer
Next Article in Special Issue
Cell-Penetrating Recombinant Peptides for Potential Use in Agricultural Pest Control Applications
Previous Article in Journal
Molecular Dynamics Simulations of Hsp90 with an Eye to Inhibitor Design
Open AccessReview

Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies

1
Department of Neurochemistry, The Arrhenius Laboratories for Natural Sciences, Stockholm University, Svante Arrhenius väg 21A, SE-106 91 Stockholm, Sweden
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhya Rd. Bangkok 10400, Thailand
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2012, 5(9), 991-1007; https://doi.org/10.3390/ph5090991
Received: 21 August 2012 / Revised: 30 August 2012 / Accepted: 6 September 2012 / Published: 12 September 2012
(This article belongs to the Special Issue Cell-penetrating Peptides 2012)
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-penetrating peptides. View Full-Text
Keywords: cell penetrating peptides; cancer; drug delivery; oligonucleotides; siRNA therapeutics; cell targeting peptides cell penetrating peptides; cancer; drug delivery; oligonucleotides; siRNA therapeutics; cell targeting peptides
Show Figures

Figure 1

MDPI and ACS Style

Regberg, J.; Srimanee, A.; Langel, Ü. Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies. Pharmaceuticals 2012, 5, 991-1007.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop