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Open AccessCommentary

In Response to: ‘Impact of Glycosylation on Effector Functions of Therapeutic IgG’ (Pharmaceuticals 2010, 3, 146–157)

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Meridian Biopharmaceuticals GmbH, Brunnerstrasse 59, 1230 Wien, Austria
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Vela Pharmazeutische Entwicklung und Laboranalytik GmbH, Brunnerstrasse 59, 1230 Wien, Austria
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Virologik GmbH, Henkestrasse 91, 91052 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(6), 1887-1891; https://doi.org/10.3390/ph3061887
Received: 29 April 2010 / Revised: 31 May 2010 / Accepted: 9 June 2010 / Published: 10 June 2010
(This article belongs to the Special Issue Monoclonal Antibody)
To complete the review article by Abes and colleagues (Pharmaceuticals 2010, 3, 146–157) which provides a good overview on recently developed approaches for generation of glyco-modified antibodies and the impact of glyco-modification of antibodies on their effector functions, important information should be added, namely that — besides the Glycart and the Biowa approach to generate de-fucosylated antibodies — innovative, moss derived methods have been shown to generate glyco-modified antibodies with improved effector function profile. View Full-Text
Keywords: therapeutic antibodies; glyco-modified IgG; ADCC; CDC; Fc -γRIII therapeutic antibodies; glyco-modified IgG; ADCC; CDC; Fc -γRIII
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MDPI and ACS Style

Nechansky, A.; Koller, I.; Kircheis, R. In Response to: ‘Impact of Glycosylation on Effector Functions of Therapeutic IgG’ (Pharmaceuticals 2010, 3, 146–157). Pharmaceuticals 2010, 3, 1887-1891.

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