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The Role of Monoclonal Antibodies in the Management of Leukemia

Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, TX 77005, USA
Department of Internal Medicine, Hematology Oncology section, Oklahoma University Health Sciences Center, 700 N.E. 13th Street, Oklahoma City, OK 74103, USA
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(10), 3258-3274;
Received: 20 September 2010 / Accepted: 18 October 2010 / Published: 18 October 2010
(This article belongs to the Special Issue Monoclonal Antibody)
This article will review the monoclonal antibodies more commonly used in leukemias. In the last three decades, scientists have made considerable progress understanding the structure and the functions of various surface antigens, such as CD20, CD33. The introduction of rituximab, an anti CD20 monoclonal antibody, had a great impact in the treatment of lymphoproliferative disorders. Gemtuzumab, an anti CD 33 conjugated monoclonal antibody has activity in acute mylegenous leukemia (AML). As this field is undergoing a rapid growth, the years will see an increasing use of monoclonal antibodies in hematological malignancies. View Full-Text
Keywords: monoclonal Abs; leukemia; CLL; AML; ALL monoclonal Abs; leukemia; CLL; AML; ALL
MDPI and ACS Style

Al-Ameri, A.; Cherry, M.; Al-Kali, A.; Ferrajoli, A. The Role of Monoclonal Antibodies in the Management of Leukemia. Pharmaceuticals 2010, 3, 3258-3274.

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