Antiproliferative Properties of Type I and Type II Interferon
Abstract
:1. Historical Perspective
2. Molecular Mechanisms of IFN Action
2.1. Cell cycle inhibition and antiproliferation
2.2. Apoptosis and Cytotoxicity
2.3. Anti-tumor
2.4. Indirect / Immunomodulatory effects of Interferon on cell growth and survival
3. Antitumor Activity of Interferon-Activated Monocytes in Vitro.
Effect of IFN-activated human monocytes on some tumor cell lines
4. Clinical Applications
4.1. Chronic Myelogenous Leukemia
4.2. Follicular Lymphoma
4.3. Malignant Melanoma
4.4. Hairy Cell Leukemia
4.5. AIDS-Related Kaposi’s Sarcoma
5. Pharmacokinetics of IFN-αs Licensed by the U.S. FDA
5.1. IFN-α2a
5.2. IFN-α2b
6. Antibodies to Interferon-α
7. Conclusions
References
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Bekisz, J.; Baron, S.; Balinsky, C.; Morrow, A.; Zoon, K.C. Antiproliferative Properties of Type I and Type II Interferon. Pharmaceuticals 2010, 3, 994-1015. https://doi.org/10.3390/ph3040994
Bekisz J, Baron S, Balinsky C, Morrow A, Zoon KC. Antiproliferative Properties of Type I and Type II Interferon. Pharmaceuticals. 2010; 3(4):994-1015. https://doi.org/10.3390/ph3040994
Chicago/Turabian StyleBekisz, Joseph, Samuel Baron, Corey Balinsky, Angel Morrow, and Kathryn C. Zoon. 2010. "Antiproliferative Properties of Type I and Type II Interferon" Pharmaceuticals 3, no. 4: 994-1015. https://doi.org/10.3390/ph3040994