Next Article in Journal
Obesity Drug Update: The Lost Decade?
Next Article in Special Issue
GPCR Conformations: Implications for Rational Drug Design
Previous Article in Journal
Allosteric Modulation of αβδ GABAA Receptors
Previous Article in Special Issue
Role of the G Protein-Coupled Receptor, mGlu1, in Melanoma Development
Open AccessReview

Jak2 Tyrosine Kinase: A Potential Therapeutic Target for AT1 Receptor Mediated Cardiovascular Disease

Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(11), 3478-3493; https://doi.org/10.3390/ph3113478
Received: 21 September 2010 / Revised: 27 October 2010 / Accepted: 8 November 2010 / Published: 9 November 2010
(This article belongs to the Special Issue GPCR Based Drug Discovery)
Patients with hypertension often manifest a dysregulated renin-angiotensin-aldosterone system (RAAS). Most of the available treatment approaches for hypertension are targeted towards the RAAS including direct renin inhibition, ACE inhibition, angiotensin II type 1 receptor (AT1-R) blockade, and aldosterone receptor antagonism. The Jak2 signaling pathway is intricately coupled to the AT1-R signaling processes involved in hypertension. Here, we review the involvement of Jak2 in the pathogenesis of hypertension, and its potential as a therapeutic target for treatment of AT1-R mediated cardiovascular disease. Jak2 may provide a rational therapeutic approach for patients whose blood pressure is not controlled by standard therapies. View Full-Text
Keywords: angiotensin II; Jak2; AT1-receptor; hypertension angiotensin II; Jak2; AT1-receptor; hypertension
Show Figures

Figure 1

MDPI and ACS Style

Kirabo, A.; Sayeski, P.P. Jak2 Tyrosine Kinase: A Potential Therapeutic Target for AT1 Receptor Mediated Cardiovascular Disease. Pharmaceuticals 2010, 3, 3478-3493.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop