Next Article in Journal
Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials
Next Article in Special Issue
Sphingosine-1-Phosphate-Specific G Protein-Coupled Receptors as Novel Therapeutic Targets for Atherosclerosis
Previous Article in Journal
Blood Pressure-Lowering Aspects of Lipid-Lowering and Anti-Diabetic Drugs
Previous Article in Special Issue
Jak2 Tyrosine Kinase: A Potential Therapeutic Target for AT1 Receptor Mediated Cardiovascular Disease
Open AccessReview

GPCR Conformations: Implications for Rational Drug Design

Department of Chemistry, The University of Memphis, Memphis, TN 38152, USA
Christian Brothers High School, 5900 Walnut Grove Road, Memphis, TN 38120, USA
Author to whom correspondence should be addressed.
Pharmaceuticals 2011, 4(1), 7-43;
Received: 24 November 2010 / Revised: 20 December 2010 / Accepted: 21 December 2010 / Published: 23 December 2010
(This article belongs to the Special Issue GPCR Based Drug Discovery)
G protein-coupled receptors (GPCRs) comprise a large class of transmembrane proteins that play critical roles in both normal physiology and pathophysiology. These critical roles offer targets for therapeutic intervention, as exemplified by the substantial fraction of current pharmaceutical agents that target members of this family. Tremendous contributions to our understanding of GPCR structure and dynamics have come from both indirect and direct structural characterization techniques. Key features of GPCR conformations derived from both types of characterization techniques are reviewed. View Full-Text
Keywords: G protein-coupled receptor; GPCR; structure; crystallography; NMR; modeling G protein-coupled receptor; GPCR; structure; crystallography; NMR; modeling
MDPI and ACS Style

Parrill, A.L.; Bautista, D.L. GPCR Conformations: Implications for Rational Drug Design. Pharmaceuticals 2011, 4, 7-43.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop