Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function

Zoladz, Phillip R.; Muñoz, Carmen; Diamond, David M.

doi:10.3390/ph3103143

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Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function

by

Phillip R. Zoladz

¹,

Carmen Muñoz

² and

David M. Diamond

^3,4,5,*

¹

Department of Psychology & Sociology, Ohio Northern University, Ada, OH 43222 USA

²

Servier International, 35 rue de Verdun, 92284 Suresnes, France

³

Research & Development Service, James A. Haley VA Hospital, Tampa, FL 33612, USA

⁴

Department of Psychology, Cognitive and Neural Sciences Division, University of South Florida, Tampa, FL 33612, USA

⁵

Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA

^*

Author to whom correspondence should be addressed.

Pharmaceuticals 2010, 3(10), 3143-3166; https://doi.org/10.3390/ph3103143

Submission received: 19 July 2010 / Revised: 26 August 2010 / Accepted: 31 August 2010 / Published: 11 October 2010

(This article belongs to the Special Issue Antidepressants)

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Abstract

Tianeptine is a well-described antidepressant which has been shown to prevent stress from producing deleterious effects on brain structure and function. Preclinical studies have shown that tianeptine blocks stress-induced alterations of neuronal morphology and synaptic plasticity. Moreover, tianeptine prevents stress from impairing learning and memory, and, importantly, demonstrates memory-enhancing properties in the absence of stress. Recent research has indicated that tianeptine works by normalizing glutamatergic neurotransmission, a mechanism of action that may underlie its effectiveness as an antidepressant. These findings emphasize the value in focusing on the mechanisms of action of tianeptine, and specifically, the glutamatergic system, in the development of novel pharmacotherapeutic strategies in the treatment of depression.

Keywords: antidepressant; synaptic plasticity; memory; animal model; glutamate; stress

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MDPI and ACS Style

Zoladz, P.R.; Muñoz, C.; Diamond, D.M. Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function. Pharmaceuticals 2010, 3, 3143-3166. https://doi.org/10.3390/ph3103143

AMA Style

Zoladz PR, Muñoz C, Diamond DM. Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function. Pharmaceuticals. 2010; 3(10):3143-3166. https://doi.org/10.3390/ph3103143

Chicago/Turabian Style

Zoladz, Phillip R., Carmen Muñoz, and David M. Diamond. 2010. "Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function" Pharmaceuticals 3, no. 10: 3143-3166. https://doi.org/10.3390/ph3103143

APA Style

Zoladz, P. R., Muñoz, C., & Diamond, D. M. (2010). Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function. Pharmaceuticals, 3(10), 3143-3166. https://doi.org/10.3390/ph3103143

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Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function

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