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Atypical Antipsychotics and Other Therapeutic Options for Treatment of Resistant Major Depressive Disorder

Institute of Mental Health, Department of Psychiatry, University of British Columbia, 5950 University Blvd. Vancouver, BC V6T 1Z3, Canada
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Pharmaceuticals 2010, 3(12), 3522-3542; https://doi.org/10.3390/ph3123522
Received: 1 November 2010 / Revised: 24 November 2010 / Accepted: 2 December 2010 / Published: 3 December 2010
(This article belongs to the Special Issue Antidepressants)
Antidepressant therapies, such as selective serotonin reuptake inhibitors (SSRIs), are current first-line treatments for Major Depressive Disorder. However, over 50% of treated patients show an inadequate response to initial antidepressant therapy. If the therapeutic outcomes from two antidepressant therapies are suboptimal, potentially resulting in Treatment Resistant Depression, subsequent strategies include switching to another antidepressant or augmenting treatment by combining with other agents. When combined with SSRIs, atypical antipsychotics have supplementary action on dopaminergic and noradrenergic systems. Studies on combined treatment with atypical antipsychotics have shown significantly increased remission rates, shortened response times, and favorable side effects. Augmentation of antidepressants with atypical antipsychotics is now an acceptable treatment strategy which leads to increased remission rates and better outcomes for patients. View Full-Text
Keywords: treatment resistant disorder; major depressive disorder; augmentation; atypical antipsychotic; typical antipsychotic; antidepressant; selective serotonin reuptake inhibitor; electroconvulsive therapy treatment resistant disorder; major depressive disorder; augmentation; atypical antipsychotic; typical antipsychotic; antidepressant; selective serotonin reuptake inhibitor; electroconvulsive therapy
MDPI and ACS Style

Seo, R.J.; MacPherson, H.; Young, A.H. Atypical Antipsychotics and Other Therapeutic Options for Treatment of Resistant Major Depressive Disorder. Pharmaceuticals 2010, 3, 3522-3542.

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