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Article

Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer

by
Adam C. Reese
1,
Jill Hardin
2,
Iona Cheng
3,
Graham Casey
4 and
John S. Witte
1,2,*
1
Department of Urology, University of California at San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA
2
Epidemiology and Biostatistics and Institute for Human Genetics, University of California at San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA
3
Epidemiology Program, Cancer Research Center of Hawai`i, University of Hawai`i, Honolulu, HI 96813, USA
4
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2010, 3(10), 3127-3142; https://doi.org/10.3390/ph3103127
Submission received: 9 August 2010 / Revised: 27 September 2010 / Accepted: 28 September 2010 / Published: 8 October 2010
(This article belongs to the Special Issue Non-Steroidal Anti-Inflammatory Drugs)
Versions Notes

Abstract

Increasing evidence suggests that prostatic inflammation plays a key role in the development of prostate cancer. It remains controversial whether non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of prostate cancer. Here, we investigate how a previously reported inverse association between NSAID use and the risk of aggressive prostate cancer is modulated by variants in several inflammatory genes. We found that NSAIDs may have differential effects on prostate cancer development, depending on one’s genetic makeup. Further study of these inflammatory pathways may clarify the mechanisms through which NSAIDs impact prostate cancer risk.
Keywords: prostatic neoplasms; non-steroidal anti-inflammatory agents; aspirin; genetic variation; single nucleotide polymorphism prostatic neoplasms; non-steroidal anti-inflammatory agents; aspirin; genetic variation; single nucleotide polymorphism

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MDPI and ACS Style

Reese, A.C.; Hardin, J.; Cheng, I.; Casey, G.; Witte, J.S. Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer. Pharmaceuticals 2010, 3, 3127-3142. https://doi.org/10.3390/ph3103127

AMA Style

Reese AC, Hardin J, Cheng I, Casey G, Witte JS. Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer. Pharmaceuticals. 2010; 3(10):3127-3142. https://doi.org/10.3390/ph3103127

Chicago/Turabian Style

Reese, Adam C., Jill Hardin, Iona Cheng, Graham Casey, and John S. Witte. 2010. "Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer" Pharmaceuticals 3, no. 10: 3127-3142. https://doi.org/10.3390/ph3103127

APA Style

Reese, A. C., Hardin, J., Cheng, I., Casey, G., & Witte, J. S. (2010). Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer. Pharmaceuticals, 3(10), 3127-3142. https://doi.org/10.3390/ph3103127

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