Previous Article in Journal
Alogliptin/Amentoflavone Combination Mitigates Bleomycin-Induced Lung Fibrosis: The Role of Oxidative Stress, TXNIP-Mediated Pyroptosis, and Autophagy/Apoptosis Balance
Previous Article in Special Issue
Machine Learning Exploration of Food-Derived Chemical Space for Potential Nutritional Metabolic Regulators Targeting Dipeptidyl Peptidase-4
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceuticals
Volume 19
Issue 6
10.3390/ph19060823
pharmaceuticals-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Tanyu Tongzhi Decoction Improves Cardiac Function by Inhibiting Platelet Activation and Alleviating Coronary Microthrombosis for Coronary Heart Disease Mice

by
Ying Yang
1,†,
Xiang Li
1,†,
Danli Tang
2,
Chengze Li
1,
Sijia Wu
3,
Yingying Li
2,
Tong Lei
1,*,
Wenjing Zong
1,* and
Huamin Zhang
1,*
1
Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
2
Experimental Research Centre of China Academy of Chinese Medical Sciences, Beijing 100700, China
3
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceuticals 2026, 19(6), 823; https://doi.org/10.3390/ph19060823
Submission received: 7 April 2026 / Revised: 15 May 2026 / Accepted: 20 May 2026 / Published: 24 May 2026
(This article belongs to the Special Issue Bioactive Compounds from Plants and Foods: From Traditional Medicine to Modern Applications in Nutrition and Health)
Versions Notes

Abstract

Background: Coronary heart disease (CHD) has a high global disease burden. According to traditional Chinese medicine theory, the main syndrome type of CHD is the syndrome of intermingled phlegm and blood stasis (SI-GPBS). Tanyu Tongzhi Decoction (TYTZD) exerts clear cardioprotective effects on CHD patients with SI-GPBS, while its specific regulatory mechanism remains unclear. Methods: Clinical serum proteomics and network pharmacology were used to screen key targets and pathways for CHD with SI-GPBS. An APOE−/− mouse model of CHD complicated with SI-GPBS was established and treated with TYTZD. Transcriptomics, proteomics and WGCNA were combined to screen core genes, with Western blotting, immunofluorescence, co-localization analysis and Carstairs staining for target verification and observation of coronary microthrombosis and endothelial injury. Results: A total of 754 differentially expressed proteins were identified in CHD patients with SI-GPBS, significantly enriched in the platelet activation pathway, with ITGA2B as the upregulated core hub protein. Network pharmacology found 94 active ingredients and 144 therapeutic targets of TYTZD for CHD with SI-GPBS, and key components bound well with ITGA2B. In APOE−/− mice with SI-GPBS, TYTZD improved cardiac function, reduced blood lipids, myocardial enzymes, aortic lipid deposition and myocardial damage, downregulated ITGA2B, F2RL2, FGA and FGB, inhibited integrin αIIbβ3 signaling, restrained endothelial activation and reduced coronary microthrombosis. Conclusions: TYTZD treats CHD with SI-GPBS mainly by inhibiting platelet activation, improving endothelial dysfunction, and reducing coronary microthrombosis. This study provides experimental basis for TYTZD’s clinical application in CHD with SI-GPBS and new ideas for TCM syndrome–disease combination research.
Keywords: coronary heart disease; multi-omics; platelet activation; network pharmacology; traditional Chinese medicine coronary heart disease; multi-omics; platelet activation; network pharmacology; traditional Chinese medicine

Share and Cite

MDPI and ACS Style

Yang, Y.; Li, X.; Tang, D.; Li, C.; Wu, S.; Li, Y.; Lei, T.; Zong, W.; Zhang, H. Tanyu Tongzhi Decoction Improves Cardiac Function by Inhibiting Platelet Activation and Alleviating Coronary Microthrombosis for Coronary Heart Disease Mice. Pharmaceuticals 2026, 19, 823. https://doi.org/10.3390/ph19060823

AMA Style

Yang Y, Li X, Tang D, Li C, Wu S, Li Y, Lei T, Zong W, Zhang H. Tanyu Tongzhi Decoction Improves Cardiac Function by Inhibiting Platelet Activation and Alleviating Coronary Microthrombosis for Coronary Heart Disease Mice. Pharmaceuticals. 2026; 19(6):823. https://doi.org/10.3390/ph19060823

Chicago/Turabian Style

Yang, Ying, Xiang Li, Danli Tang, Chengze Li, Sijia Wu, Yingying Li, Tong Lei, Wenjing Zong, and Huamin Zhang. 2026. "Tanyu Tongzhi Decoction Improves Cardiac Function by Inhibiting Platelet Activation and Alleviating Coronary Microthrombosis for Coronary Heart Disease Mice" Pharmaceuticals 19, no. 6: 823. https://doi.org/10.3390/ph19060823

APA Style

Yang, Y., Li, X., Tang, D., Li, C., Wu, S., Li, Y., Lei, T., Zong, W., & Zhang, H. (2026). Tanyu Tongzhi Decoction Improves Cardiac Function by Inhibiting Platelet Activation and Alleviating Coronary Microthrombosis for Coronary Heart Disease Mice. Pharmaceuticals, 19(6), 823. https://doi.org/10.3390/ph19060823

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop